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Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study
Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132236/ https://www.ncbi.nlm.nih.gov/pubmed/32266024 http://dx.doi.org/10.3892/etm.2020.8582 |
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author | Yoo, Kwang Ho Kwon, Tae-Rin Oh, Chang Taek Ko, Kyeung Chan No, Yong Hwan Oh, Won Jong Kim, Beom Joon |
author_facet | Yoo, Kwang Ho Kwon, Tae-Rin Oh, Chang Taek Ko, Kyeung Chan No, Yong Hwan Oh, Won Jong Kim, Beom Joon |
author_sort | Yoo, Kwang Ho |
collection | PubMed |
description | Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight. The purpose of the present study was to assess the improvement of the slimming cream's efficacy using a novel fabric, with the aim of developing an improved method for transdermal drug delivery. The current study was conducted on four groups of guinea pigs. The control group was untreated, whereas the test groups were treated with either slimming cream and no fabric, slimming cream with 100% cotton fabric or slimming cream with the novel fabric. Ultrasound and microscopic histological analysis were used to assess animals. The results demonstrated that compared with the other groups, the novel fabric group demonstrated the greatest reductions in fat layer thickness, adipocyte size and number and proliferator-activated receptor-γ levels in adipose tissue. Furthermore, the novel fabric also enhanced the transdermal delivery of rhodamine B base and caffeine penetration compared with the control fabric (3.18-fold). In conclusion, the results of the present study demonstrated that the novel fabric can potentially be used to enhance transdermal drug delivery. |
format | Online Article Text |
id | pubmed-7132236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-71322362020-04-07 Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study Yoo, Kwang Ho Kwon, Tae-Rin Oh, Chang Taek Ko, Kyeung Chan No, Yong Hwan Oh, Won Jong Kim, Beom Joon Exp Ther Med Articles Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight. The purpose of the present study was to assess the improvement of the slimming cream's efficacy using a novel fabric, with the aim of developing an improved method for transdermal drug delivery. The current study was conducted on four groups of guinea pigs. The control group was untreated, whereas the test groups were treated with either slimming cream and no fabric, slimming cream with 100% cotton fabric or slimming cream with the novel fabric. Ultrasound and microscopic histological analysis were used to assess animals. The results demonstrated that compared with the other groups, the novel fabric group demonstrated the greatest reductions in fat layer thickness, adipocyte size and number and proliferator-activated receptor-γ levels in adipose tissue. Furthermore, the novel fabric also enhanced the transdermal delivery of rhodamine B base and caffeine penetration compared with the control fabric (3.18-fold). In conclusion, the results of the present study demonstrated that the novel fabric can potentially be used to enhance transdermal drug delivery. D.A. Spandidos 2020-05 2020-03-06 /pmc/articles/PMC7132236/ /pubmed/32266024 http://dx.doi.org/10.3892/etm.2020.8582 Text en Copyright: © Yoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Articles Yoo, Kwang Ho Kwon, Tae-Rin Oh, Chang Taek Ko, Kyeung Chan No, Yong Hwan Oh, Won Jong Kim, Beom Joon Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title | Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title_full | Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title_fullStr | Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title_full_unstemmed | Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title_short | Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study |
title_sort | improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: an in vivo and in vitro study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132236/ https://www.ncbi.nlm.nih.gov/pubmed/32266024 http://dx.doi.org/10.3892/etm.2020.8582 |
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