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Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR–Cas complex revealed by cryo-EM

Prokaryotes and viruses have fought a long battle against each other. Prokaryotes use CRISPR–Cas-mediated adaptive immunity, while conversely, viruses evolve multiple anti-CRISPR (Acr) proteins to defeat these CRISPR–Cas systems. The type I-F CRISPR–Cas system in Pseudomonas aeruginosa requires the...

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Detalles Bibliográficos
Autores principales:	Zhang, Kaiming, Wang, Shuo, Li, Shanshan, Zhu, Yuwei, Pintilie, Grigore D., Mou, Tung-Chung, Schmid, Michael F., Huang, Zhiwei, Chiu, Wah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132274/ https://www.ncbi.nlm.nih.gov/pubmed/32170016 http://dx.doi.org/10.1073/pnas.1922638117

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