A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

Cholesterol biosynthesis is a high-cost process and, therefore, tightly regulated by both transcriptional and posttranslational negative feedback mechanisms in response to the level of cellular cholesterol. Squalene monooxygenase (SM, also known as squalene epoxidase or SQLE) is a rate-limiting enzy...

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Detalles Bibliográficos
Autores principales: Yoshioka, Hiromasa, Coates, Hudson W., Chua, Ngee Kiat, Hashimoto, Yuichi, Brown, Andrew J., Ohgane, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132291/
https://www.ncbi.nlm.nih.gov/pubmed/32170014
http://dx.doi.org/10.1073/pnas.1915923117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132291/
https://www.ncbi.nlm.nih.gov/pubmed/32170014
http://dx.doi.org/10.1073/pnas.1915923117

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