EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

Eps15-homology domain containing protein 2 (EHD2) is a dynamin-related ATPase located at the neck of caveolae, but its physiological function has remained unclear. Here, we found that global genetic ablation of EHD2 in mice leads to increased lipid droplet size in fat tissue. This organismic phenoty...

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Detalles Bibliográficos
Autores principales: Matthaeus, Claudia, Lahmann, Ines, Kunz, Séverine, Jonas, Wenke, Melo, Arthur Alves, Lehmann, Martin, Larsson, Elin, Lundmark, Richard, Kern, Matthias, Blüher, Matthias, Olschowski, Hannah, Kompa, Julian, Brügger, Britta, Müller, Dominik N., Haucke, Volker, Schürmann, Annette, Birchmeier, Carmen, Daumke, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132307/
https://www.ncbi.nlm.nih.gov/pubmed/32170013
http://dx.doi.org/10.1073/pnas.1918415117

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