Bioactivities and Future Perspectives of Chaetoglobosins

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have foun...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jinhua, Zhang, Wenzhou, Guo, Qingfeng, Yu, Weijiang, Zhang, Yongna, He, Baoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132351/
https://www.ncbi.nlm.nih.gov/pubmed/32308719
http://dx.doi.org/10.1155/2020/8574084
Descripción
Sumario:Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

Ejemplares similares