Cargando…

Medication adherence to first-line antihypertensive drug class in a large Chinese population()

PURPOSE: Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. METHODS: All patients prescribed ≥ one antihypertensive drug...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Martin C.S., Tam, Wilson W.S., Cheung, Clement S.K., Tong, Ellen L.H., Sek, Antonio C.H., Cheung, N.T., Leeder, Stephen, Griffiths, Sian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ireland Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132368/
https://www.ncbi.nlm.nih.gov/pubmed/22560948
http://dx.doi.org/10.1016/j.ijcard.2012.04.060
_version_ 1783517421603127296
author Wong, Martin C.S.
Tam, Wilson W.S.
Cheung, Clement S.K.
Tong, Ellen L.H.
Sek, Antonio C.H.
Cheung, N.T.
Leeder, Stephen
Griffiths, Sian
author_facet Wong, Martin C.S.
Tam, Wilson W.S.
Cheung, Clement S.K.
Tong, Ellen L.H.
Sek, Antonio C.H.
Cheung, N.T.
Leeder, Stephen
Griffiths, Sian
author_sort Wong, Martin C.S.
collection PubMed
description PURPOSE: Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. METHODS: All patients prescribed ≥ one antihypertensive drug in 2001–2003 and 2005 who have paid at least two consecutive clinic visits in the public healthcare system of Hong Kong were included. We excluded patients who have followed-up in the clinics for ≤ 30 days. Interval-based Proportion of Days Covered (PDC) was used to assess medication adherence. All patients were followed-up for up to 5 years. Binary logistic regression analysis was used to evaluate the factors associated with optimal adherence, defined as PDC ≥ 80%. RESULTS: From 147,914 eligible patients, 69.2% were adherent to the antihypertensive prescriptions. When compared with angiotensin converting enzyme inhibitors (ACEIs), patients initially prescribed α-blockers (adjusted odds ratio [AOR] = 0.234, 95% C.I. 0.215–0.256), β-blockers (AOR = 0.447, 95% C.I. 0.420, 0.477), thiazide diuretics (AOR = 0.431 95% C.I. 0.399, 0.466) and calcium channel blockers (AOR = 0.451, 95% C.I. 0.423, 0.481) were significantly less likely to be drug adherers. Angiotensin receptor blockers (ARBs) and fixed-dose combination therapies were similarly likely to be medication adherent. Older age, male gender, visits in general out-patient clinics, residence in urbanized regions, and the presence of comorbidity were positively associated with optimal drug adherence. CONCLUSION: Patients receiving initial prescriptions of ACEIs, ARB and combination therapy had more favorable adherence profiles than the other major antihypertensive classes in real-life clinical practice.
format Online
Article
Text
id pubmed-7132368
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier Ireland Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71323682020-04-08 Medication adherence to first-line antihypertensive drug class in a large Chinese population() Wong, Martin C.S. Tam, Wilson W.S. Cheung, Clement S.K. Tong, Ellen L.H. Sek, Antonio C.H. Cheung, N.T. Leeder, Stephen Griffiths, Sian Int J Cardiol Article PURPOSE: Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. METHODS: All patients prescribed ≥ one antihypertensive drug in 2001–2003 and 2005 who have paid at least two consecutive clinic visits in the public healthcare system of Hong Kong were included. We excluded patients who have followed-up in the clinics for ≤ 30 days. Interval-based Proportion of Days Covered (PDC) was used to assess medication adherence. All patients were followed-up for up to 5 years. Binary logistic regression analysis was used to evaluate the factors associated with optimal adherence, defined as PDC ≥ 80%. RESULTS: From 147,914 eligible patients, 69.2% were adherent to the antihypertensive prescriptions. When compared with angiotensin converting enzyme inhibitors (ACEIs), patients initially prescribed α-blockers (adjusted odds ratio [AOR] = 0.234, 95% C.I. 0.215–0.256), β-blockers (AOR = 0.447, 95% C.I. 0.420, 0.477), thiazide diuretics (AOR = 0.431 95% C.I. 0.399, 0.466) and calcium channel blockers (AOR = 0.451, 95% C.I. 0.423, 0.481) were significantly less likely to be drug adherers. Angiotensin receptor blockers (ARBs) and fixed-dose combination therapies were similarly likely to be medication adherent. Older age, male gender, visits in general out-patient clinics, residence in urbanized regions, and the presence of comorbidity were positively associated with optimal drug adherence. CONCLUSION: Patients receiving initial prescriptions of ACEIs, ARB and combination therapy had more favorable adherence profiles than the other major antihypertensive classes in real-life clinical practice. Elsevier Ireland Ltd. 2013-08-20 2012-05-03 /pmc/articles/PMC7132368/ /pubmed/22560948 http://dx.doi.org/10.1016/j.ijcard.2012.04.060 Text en Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wong, Martin C.S.
Tam, Wilson W.S.
Cheung, Clement S.K.
Tong, Ellen L.H.
Sek, Antonio C.H.
Cheung, N.T.
Leeder, Stephen
Griffiths, Sian
Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title_full Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title_fullStr Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title_full_unstemmed Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title_short Medication adherence to first-line antihypertensive drug class in a large Chinese population()
title_sort medication adherence to first-line antihypertensive drug class in a large chinese population()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132368/
https://www.ncbi.nlm.nih.gov/pubmed/22560948
http://dx.doi.org/10.1016/j.ijcard.2012.04.060
work_keys_str_mv AT wongmartincs medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT tamwilsonws medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT cheungclementsk medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT tongellenlh medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT sekantonioch medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT cheungnt medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT leederstephen medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation
AT griffithssian medicationadherencetofirstlineantihypertensivedrugclassinalargechinesepopulation