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The role of infection in Kawasaki syndrome

OBJECTIVES: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). METHODS: PubMed was searched for all of the studies published over the last 15 years using the key words “Kawasaki syndrome” or “mucocutaneous lymph node syndrome” and “infectious disease” or “gene...

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Autores principales: Principi, Nicola, Rigante, Donato, Esposito, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132405/
https://www.ncbi.nlm.nih.gov/pubmed/23603251
http://dx.doi.org/10.1016/j.jinf.2013.04.004
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author Principi, Nicola
Rigante, Donato
Esposito, Susanna
author_facet Principi, Nicola
Rigante, Donato
Esposito, Susanna
author_sort Principi, Nicola
collection PubMed
description OBJECTIVES: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). METHODS: PubMed was searched for all of the studies published over the last 15 years using the key words “Kawasaki syndrome” or “mucocutaneous lymph node syndrome” and “infectious disease” or “genetics” or “vasculitis” or “pathogenesis”. RESULTS: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. CONCLUSIONS: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease.
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spelling pubmed-71324052020-04-08 The role of infection in Kawasaki syndrome Principi, Nicola Rigante, Donato Esposito, Susanna J Infect Review OBJECTIVES: To analyse the evidence suggesting a possible infectious origin of Kawasaki syndrome (KS). METHODS: PubMed was searched for all of the studies published over the last 15 years using the key words “Kawasaki syndrome” or “mucocutaneous lymph node syndrome” and “infectious disease” or “genetics” or “vasculitis” or “pathogenesis”. RESULTS: Various levels of evidence support the hypothesis that KS is a complex disease triggered by an infection due to one or more pathogens. Viruses or bacteria may be the primum movens, although no specific infectious agent can be considered definitely etiological. A number of genetic polymorphisms have been identified in subjects with KS, but none of them can currently be considered a real marker of susceptibility. CONCLUSIONS: Various data suggest that KS is intimately related to infectious diseases and that its clinical expression is influenced by predisposing genetic backgrounds, but our knowledge of the infectious agent(s) involved and the genetic characteristics of susceptible children remains only partial. Further studies are needed to address the many still open questions concerning the disease. The British Infection Association. Published by Elsevier Ltd. 2013-07 2013-04-18 /pmc/articles/PMC7132405/ /pubmed/23603251 http://dx.doi.org/10.1016/j.jinf.2013.04.004 Text en Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Principi, Nicola
Rigante, Donato
Esposito, Susanna
The role of infection in Kawasaki syndrome
title The role of infection in Kawasaki syndrome
title_full The role of infection in Kawasaki syndrome
title_fullStr The role of infection in Kawasaki syndrome
title_full_unstemmed The role of infection in Kawasaki syndrome
title_short The role of infection in Kawasaki syndrome
title_sort role of infection in kawasaki syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132405/
https://www.ncbi.nlm.nih.gov/pubmed/23603251
http://dx.doi.org/10.1016/j.jinf.2013.04.004
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