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A review of experimental infections with bluetongue virus in the mammalian host

Experimental infection studies with bluetongue virus (BTV) in the mammalian host have a history that stretches back to the late 18th century. Studies in a wide range of ruminant and camelid species as well as mice have been instrumental in understanding BTV transmission, bluetongue (BT) pathogenicit...

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Autores principales: Coetzee, Peter, van Vuuren, Moritz, Venter, Estelle. H., Stokstad, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132480/
https://www.ncbi.nlm.nih.gov/pubmed/24462840
http://dx.doi.org/10.1016/j.virusres.2013.12.044
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author Coetzee, Peter
van Vuuren, Moritz
Venter, Estelle. H.
Stokstad, Maria
author_facet Coetzee, Peter
van Vuuren, Moritz
Venter, Estelle. H.
Stokstad, Maria
author_sort Coetzee, Peter
collection PubMed
description Experimental infection studies with bluetongue virus (BTV) in the mammalian host have a history that stretches back to the late 18th century. Studies in a wide range of ruminant and camelid species as well as mice have been instrumental in understanding BTV transmission, bluetongue (BT) pathogenicity/pathogenesis, viral virulence, the induced immune response, as well as reproductive failures associated with BTV infection. These studies have in many cases been complemented by in vitro studies with BTV in different cell types in tissue culture. Together these studies have formed the basis for the understanding of BTV-host interaction and have contributed to the design of successful control strategies, including the development of effective vaccines. This review describes some of the fundamental and contemporary infection studies that have been conducted with BTV in the mammalian host and provides an overview of the principal animal welfare issues that should be considered when designing experimental infection studies with BTV in in vivo infection models. Examples are provided from the authors’ own laboratory where the three Rs (replacement, reduction and refinement) have been implemented in the design of experimental infection studies with BTV in mice and goats. The use of the ARRIVE guidelines for the reporting of data from animal infection studies is emphasized.
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spelling pubmed-71324802020-04-08 A review of experimental infections with bluetongue virus in the mammalian host Coetzee, Peter van Vuuren, Moritz Venter, Estelle. H. Stokstad, Maria Virus Res Article Experimental infection studies with bluetongue virus (BTV) in the mammalian host have a history that stretches back to the late 18th century. Studies in a wide range of ruminant and camelid species as well as mice have been instrumental in understanding BTV transmission, bluetongue (BT) pathogenicity/pathogenesis, viral virulence, the induced immune response, as well as reproductive failures associated with BTV infection. These studies have in many cases been complemented by in vitro studies with BTV in different cell types in tissue culture. Together these studies have formed the basis for the understanding of BTV-host interaction and have contributed to the design of successful control strategies, including the development of effective vaccines. This review describes some of the fundamental and contemporary infection studies that have been conducted with BTV in the mammalian host and provides an overview of the principal animal welfare issues that should be considered when designing experimental infection studies with BTV in in vivo infection models. Examples are provided from the authors’ own laboratory where the three Rs (replacement, reduction and refinement) have been implemented in the design of experimental infection studies with BTV in mice and goats. The use of the ARRIVE guidelines for the reporting of data from animal infection studies is emphasized. Elsevier B.V. 2014-03-28 2014-01-23 /pmc/articles/PMC7132480/ /pubmed/24462840 http://dx.doi.org/10.1016/j.virusres.2013.12.044 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Coetzee, Peter
van Vuuren, Moritz
Venter, Estelle. H.
Stokstad, Maria
A review of experimental infections with bluetongue virus in the mammalian host
title A review of experimental infections with bluetongue virus in the mammalian host
title_full A review of experimental infections with bluetongue virus in the mammalian host
title_fullStr A review of experimental infections with bluetongue virus in the mammalian host
title_full_unstemmed A review of experimental infections with bluetongue virus in the mammalian host
title_short A review of experimental infections with bluetongue virus in the mammalian host
title_sort review of experimental infections with bluetongue virus in the mammalian host
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132480/
https://www.ncbi.nlm.nih.gov/pubmed/24462840
http://dx.doi.org/10.1016/j.virusres.2013.12.044
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