The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity

Dendritic cells which are located at the interface of innate and adaptive immunity are targets for infection by many different DNA and RNA viruses. Dendritic cell subpopulations express specific nucleic acid recognition receptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and the cyt...

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Autores principales: Eisenächer, Katharina, Steinberg, Christian, Reindl, Wolfgang, Krug, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132487/
https://www.ncbi.nlm.nih.gov/pubmed/18086372
http://dx.doi.org/10.1016/j.imbio.2007.09.007
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author Eisenächer, Katharina
Steinberg, Christian
Reindl, Wolfgang
Krug, Anne
author_facet Eisenächer, Katharina
Steinberg, Christian
Reindl, Wolfgang
Krug, Anne
author_sort Eisenächer, Katharina
collection PubMed
description Dendritic cells which are located at the interface of innate and adaptive immunity are targets for infection by many different DNA and RNA viruses. Dendritic cell subpopulations express specific nucleic acid recognition receptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and the cytosolic RNA helicase family (RIG-I, MDA5, LGP2). Activation of dendritic cells by viral DNA and RNA via these receptors is essential for triggering the innate antiviral immune response and shaping the ensuing adaptive antiviral immunity. This review will summarize our current knowledge of viral nucleic acid recognition and signaling by Toll-like receptors and RNA helicases focusing on recent evidence for their specific functions in antiviral defense in vivo.
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spelling pubmed-71324872020-04-08 The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity Eisenächer, Katharina Steinberg, Christian Reindl, Wolfgang Krug, Anne Immunobiology Article Dendritic cells which are located at the interface of innate and adaptive immunity are targets for infection by many different DNA and RNA viruses. Dendritic cell subpopulations express specific nucleic acid recognition receptors belonging to the Toll-like receptor family (TLR3, 7, 8, 9) and the cytosolic RNA helicase family (RIG-I, MDA5, LGP2). Activation of dendritic cells by viral DNA and RNA via these receptors is essential for triggering the innate antiviral immune response and shaping the ensuing adaptive antiviral immunity. This review will summarize our current knowledge of viral nucleic acid recognition and signaling by Toll-like receptors and RNA helicases focusing on recent evidence for their specific functions in antiviral defense in vivo. Elsevier GmbH. 2008-01-18 2007-11-09 /pmc/articles/PMC7132487/ /pubmed/18086372 http://dx.doi.org/10.1016/j.imbio.2007.09.007 Text en Copyright © 2007 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Eisenächer, Katharina
Steinberg, Christian
Reindl, Wolfgang
Krug, Anne
The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title_full The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title_fullStr The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title_full_unstemmed The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title_short The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
title_sort role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132487/
https://www.ncbi.nlm.nih.gov/pubmed/18086372
http://dx.doi.org/10.1016/j.imbio.2007.09.007
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