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Evaluating the virucidal efficacy of hydrogen peroxide vapour

BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, fo...

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Autores principales: Goyal, S.M., Chander, Y., Yezli, S., Otter, J.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Healthcare Infection Society. Published by Elsevier Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132520/
https://www.ncbi.nlm.nih.gov/pubmed/24656442
http://dx.doi.org/10.1016/j.jhin.2014.02.003
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author Goyal, S.M.
Chander, Y.
Yezli, S.
Otter, J.A.
author_facet Goyal, S.M.
Chander, Y.
Yezli, S.
Otter, J.A.
author_sort Goyal, S.M.
collection PubMed
description BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV). METHODS: The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m(3) environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33 mL. FINDINGS: No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25 mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes. CONCLUSION: HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces.
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spelling pubmed-71325202020-04-08 Evaluating the virucidal efficacy of hydrogen peroxide vapour Goyal, S.M. Chander, Y. Yezli, S. Otter, J.A. J Hosp Infect Article BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV). METHODS: The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m(3) environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33 mL. FINDINGS: No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25 mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes. CONCLUSION: HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces. The Healthcare Infection Society. Published by Elsevier Ltd. 2014-04 2014-02-27 /pmc/articles/PMC7132520/ /pubmed/24656442 http://dx.doi.org/10.1016/j.jhin.2014.02.003 Text en Copyright © 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Goyal, S.M.
Chander, Y.
Yezli, S.
Otter, J.A.
Evaluating the virucidal efficacy of hydrogen peroxide vapour
title Evaluating the virucidal efficacy of hydrogen peroxide vapour
title_full Evaluating the virucidal efficacy of hydrogen peroxide vapour
title_fullStr Evaluating the virucidal efficacy of hydrogen peroxide vapour
title_full_unstemmed Evaluating the virucidal efficacy of hydrogen peroxide vapour
title_short Evaluating the virucidal efficacy of hydrogen peroxide vapour
title_sort evaluating the virucidal efficacy of hydrogen peroxide vapour
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132520/
https://www.ncbi.nlm.nih.gov/pubmed/24656442
http://dx.doi.org/10.1016/j.jhin.2014.02.003
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