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Evaluating the virucidal efficacy of hydrogen peroxide vapour
BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, fo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Healthcare Infection Society. Published by Elsevier Ltd.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132520/ https://www.ncbi.nlm.nih.gov/pubmed/24656442 http://dx.doi.org/10.1016/j.jhin.2014.02.003 |
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author | Goyal, S.M. Chander, Y. Yezli, S. Otter, J.A. |
author_facet | Goyal, S.M. Chander, Y. Yezli, S. Otter, J.A. |
author_sort | Goyal, S.M. |
collection | PubMed |
description | BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV). METHODS: The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m(3) environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33 mL. FINDINGS: No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25 mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes. CONCLUSION: HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces. |
format | Online Article Text |
id | pubmed-7132520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Healthcare Infection Society. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71325202020-04-08 Evaluating the virucidal efficacy of hydrogen peroxide vapour Goyal, S.M. Chander, Y. Yezli, S. Otter, J.A. J Hosp Infect Article BACKGROUND: Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. AIM: To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV). METHODS: The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m(3) environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33 mL. FINDINGS: No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25 mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes. CONCLUSION: HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces. The Healthcare Infection Society. Published by Elsevier Ltd. 2014-04 2014-02-27 /pmc/articles/PMC7132520/ /pubmed/24656442 http://dx.doi.org/10.1016/j.jhin.2014.02.003 Text en Copyright © 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Goyal, S.M. Chander, Y. Yezli, S. Otter, J.A. Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title | Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title_full | Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title_fullStr | Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title_full_unstemmed | Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title_short | Evaluating the virucidal efficacy of hydrogen peroxide vapour |
title_sort | evaluating the virucidal efficacy of hydrogen peroxide vapour |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132520/ https://www.ncbi.nlm.nih.gov/pubmed/24656442 http://dx.doi.org/10.1016/j.jhin.2014.02.003 |
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