Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity

Antibodies against the HIV-1 V1V2 loops were the only correlate of reduced infection risk in the RV144 vaccine trial, highlighting the V1V2 loops as promising targets for vaccine design. The V1V2 loops are structurally plastic, exhibiting either an α-helix-coil or β-strand conformation. V1V2-specifi...

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Detalles Bibliográficos
Autores principales: Lai, Jennifer I., Eszterhas, Susan K., Brooks, Seth A., Guo, Chengzi, Zolla-Pazner, Susan, Seaman, Michael S., Bailey-Kellogg, Chris, Griswold, Karl E., Ackerman, Margaret E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132531/
https://www.ncbi.nlm.nih.gov/pubmed/32192810
http://dx.doi.org/10.1016/j.vaccine.2020.03.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132531/
https://www.ncbi.nlm.nih.gov/pubmed/32192810
http://dx.doi.org/10.1016/j.vaccine.2020.03.010

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