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Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer

OBJECTIVE: Diagnosing gastric cancer (GC) at early stages is important for reducing its mortality. This study evaluated the diagnostic value of serum pepsinogen (PG) I, PGII, and gastrin-17 (G17) levels in screening for early-stage GC. METHODS: Serum levels of PGI, PGII, and G17 were measured in pat...

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Autores principales: Wang, Yaping, Zhu, Zhiyong, Liu, Zhilan, Zhao, Zhen, Xue, Xiaohong, Li, Xiaolin, Li, Pingying, Rong, Guanghong, Ma, Yingcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132564/
https://www.ncbi.nlm.nih.gov/pubmed/32228342
http://dx.doi.org/10.1177/0300060520914826
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author Wang, Yaping
Zhu, Zhiyong
Liu, Zhilan
Zhao, Zhen
Xue, Xiaohong
Li, Xiaolin
Li, Pingying
Rong, Guanghong
Ma, Yingcai
author_facet Wang, Yaping
Zhu, Zhiyong
Liu, Zhilan
Zhao, Zhen
Xue, Xiaohong
Li, Xiaolin
Li, Pingying
Rong, Guanghong
Ma, Yingcai
author_sort Wang, Yaping
collection PubMed
description OBJECTIVE: Diagnosing gastric cancer (GC) at early stages is important for reducing its mortality. This study evaluated the diagnostic value of serum pepsinogen (PG) I, PGII, and gastrin-17 (G17) levels in screening for early-stage GC. METHODS: Serum levels of PGI, PGII, and G17 were measured in patients with upper digestive tract symptoms or GC family histories, and the PGI to PGII ratio (PGR) was calculated. Receiver operator characteristic curves were used to determine the thresholds of PGI, PGR, and G17 for GC diagnosis. RESULTS: Among the 949 patients examined by gastroscopy, 13 (1.37%) had GC, including five cases of early-stage GC and eight cases of progressive GC. PGI, PGR, and G17 showed good specificity and sensitivity for early-stage and progressive GC. The optimal thresholds of PGI, G17, and PGR were 71.85 μg/L, 15.65 pmol/L and 5.04 for the diagnosis of early-stage GC, respectively, and were 42.55 μg/L, 20.55 pmol/L, and 2.79 for the diagnosis of progressive GC, respectively. CONCLUSION: Combining PG and G17 serum levels with gastroscopy could be a promising approach to screen for early-stage GC.
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spelling pubmed-71325642020-04-13 Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer Wang, Yaping Zhu, Zhiyong Liu, Zhilan Zhao, Zhen Xue, Xiaohong Li, Xiaolin Li, Pingying Rong, Guanghong Ma, Yingcai J Int Med Res Prospective Clinical Research Report OBJECTIVE: Diagnosing gastric cancer (GC) at early stages is important for reducing its mortality. This study evaluated the diagnostic value of serum pepsinogen (PG) I, PGII, and gastrin-17 (G17) levels in screening for early-stage GC. METHODS: Serum levels of PGI, PGII, and G17 were measured in patients with upper digestive tract symptoms or GC family histories, and the PGI to PGII ratio (PGR) was calculated. Receiver operator characteristic curves were used to determine the thresholds of PGI, PGR, and G17 for GC diagnosis. RESULTS: Among the 949 patients examined by gastroscopy, 13 (1.37%) had GC, including five cases of early-stage GC and eight cases of progressive GC. PGI, PGR, and G17 showed good specificity and sensitivity for early-stage and progressive GC. The optimal thresholds of PGI, G17, and PGR were 71.85 μg/L, 15.65 pmol/L and 5.04 for the diagnosis of early-stage GC, respectively, and were 42.55 μg/L, 20.55 pmol/L, and 2.79 for the diagnosis of progressive GC, respectively. CONCLUSION: Combining PG and G17 serum levels with gastroscopy could be a promising approach to screen for early-stage GC. SAGE Publications 2020-03-31 /pmc/articles/PMC7132564/ /pubmed/32228342 http://dx.doi.org/10.1177/0300060520914826 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Wang, Yaping
Zhu, Zhiyong
Liu, Zhilan
Zhao, Zhen
Xue, Xiaohong
Li, Xiaolin
Li, Pingying
Rong, Guanghong
Ma, Yingcai
Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title_full Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title_fullStr Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title_full_unstemmed Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title_short Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer
title_sort diagnostic value of serum pepsinogen i, pepsinogen ii, and gastrin-17 levels for population-based screening for early-stage gastric cancer
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132564/
https://www.ncbi.nlm.nih.gov/pubmed/32228342
http://dx.doi.org/10.1177/0300060520914826
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