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Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population
Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-co...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132661/ https://www.ncbi.nlm.nih.gov/pubmed/19445991 http://dx.doi.org/10.1016/j.humimm.2009.05.006 |
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author | Keicho, Naoto Itoyama, Satoru Kashiwase, Koichi Phi, Nguyen Chi Long, Hoang Thuy Ha, Le Dang Ban, Vo Van Hoa, Bach Khanh Hang, Nguyen Thi Le Hijikata, Minako Sakurada, Shinsaku Satake, Masahiro Tokunaga, Katsushi Sasazuki, Takehiko Quy, Tran |
author_facet | Keicho, Naoto Itoyama, Satoru Kashiwase, Koichi Phi, Nguyen Chi Long, Hoang Thuy Ha, Le Dang Ban, Vo Van Hoa, Bach Khanh Hang, Nguyen Thi Le Hijikata, Minako Sakurada, Shinsaku Satake, Masahiro Tokunaga, Katsushi Sasazuki, Takehiko Quy, Tran |
author_sort | Keicho, Naoto |
collection | PubMed |
description | Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases. |
format | Online Article Text |
id | pubmed-7132661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71326612020-04-08 Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population Keicho, Naoto Itoyama, Satoru Kashiwase, Koichi Phi, Nguyen Chi Long, Hoang Thuy Ha, Le Dang Ban, Vo Van Hoa, Bach Khanh Hang, Nguyen Thi Le Hijikata, Minako Sakurada, Shinsaku Satake, Masahiro Tokunaga, Katsushi Sasazuki, Takehiko Quy, Tran Hum Immunol Article Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases. American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. 2009-07 2009-05-13 /pmc/articles/PMC7132661/ /pubmed/19445991 http://dx.doi.org/10.1016/j.humimm.2009.05.006 Text en Copyright © 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Keicho, Naoto Itoyama, Satoru Kashiwase, Koichi Phi, Nguyen Chi Long, Hoang Thuy Ha, Le Dang Ban, Vo Van Hoa, Bach Khanh Hang, Nguyen Thi Le Hijikata, Minako Sakurada, Shinsaku Satake, Masahiro Tokunaga, Katsushi Sasazuki, Takehiko Quy, Tran Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title | Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title_full | Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title_fullStr | Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title_full_unstemmed | Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title_short | Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population |
title_sort | association of human leukocyte antigen class ii alleles with severe acute respiratory syndrome in the vietnamese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132661/ https://www.ncbi.nlm.nih.gov/pubmed/19445991 http://dx.doi.org/10.1016/j.humimm.2009.05.006 |
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