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Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia

BACKGROUND: The enzyme farnesyl diphosphate synthase (FPPS) is positioned in the intersection of different sterol biosynthesis pathways such as those producing isoprenoids, dolichols and ergosterol. FPPS is ubiquitous in eukaryotes and is inhibited by nitrogen-containing bisphosphonates (N-BP). N-BP...

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Detalles Bibliográficos
Autores principales:	Gadelha, Ana Paula R., Brigagao, Claudia Maia, da Silva, Martha Barros, Rodrigues, Aline Beatriz Mello, Guimarães, Ana Carolina Ramos, Paiva, Fernando, de Souza, Wanderley, Henriques, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132869/ https://www.ncbi.nlm.nih.gov/pubmed/32248823 http://dx.doi.org/10.1186/s13071-020-04019-z

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