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Preserved Calretinin Interneurons in an App Model of Alzheimer’s Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors
To understand the pathogenesis of specific neuronal circuit dysfunction in Alzheimer’s disease (AD), we investigated the fate of three subclasses of “modulatory interneurons” in hippocampal CA1 using the App(NL-F/NL-F) knock-in mouse model of AD. Cholecystokinin- and somatostatin-expressing interneu...
Autores principales: | Shi, Anqi, Petrache, Alexandra L, Shi, Jiachen, Ali, Afia B |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132926/ https://www.ncbi.nlm.nih.gov/pubmed/31407772 http://dx.doi.org/10.1093/cercor/bhz165 |
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