Cargando…

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Shank2 knockout mouse shows ASD-like behavioral phenotypes, including social deficits. Intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yong-Seok, Yu, Nam-Kyung, Chun, Jeewan, Yang, Jung-eun, Lim, Chae-Seok, Kim, Hyopil, Park, Gaeun, Lee, Jin-A, Lee, Kyungmin, Kaang, Bong-Kiun, Lee, Jae-Hyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132969/ https://www.ncbi.nlm.nih.gov/pubmed/32252796 http://dx.doi.org/10.1186/s13041-020-00595-4

Ejemplares similares

Reduced acute nociception and chronic pain in Shank2(−/−) mice
por: Ko, Hyoung-Gon, et al.
Publicado: (2016)

Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorder
por: Kim, Hyopil, et al.
Publicado: (2016)

Increased social interaction in Shank2-deficient mice following acute social isolation
por: Choi, Ja Eun, et al.
Publicado: (2023)

Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7(–/–) Mice
por: Wegener, Stephanie, et al.
Publicado: (2018)

Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
por: Han, Kyung Ah, et al.
Publicado: (2020)

A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity
por: Yoon, Seo-Yeon, et al.
Publicado: (2017)

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
por: Wang, Xiaoming, et al.
Publicado: (2014)

Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients
por: Lim, Chae-Seok, et al.
Publicado: (2015)

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
por: Wang, Li, et al.
Publicado: (2019)

Downregulation of the Autism Spectrum Disorder Gene Shank2 Decreases Bone Mass in Male Mice
por: Ahmad, Mubashir, et al.
Publicado: (2022)

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice
por: Lim, Chae-Seok, et al.
Publicado: (2021)

Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants
por: Eltokhi, Ahmed, et al.
Publicado: (2018)

Lack of Association between NLGN3, NLGN4, SHANK2 and SHANK3 Gene Variants and Autism Spectrum Disorder in a Chinese Population
por: Liu, Yanyan, et al.
Publicado: (2013)

Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder
por: Hulbert, Samuel W., et al.
Publicado: (2018)

Novel Therapeutic Approach for Autism Spectrum Disorder: Focus on SHANK3
por: Uchino, Shigeo, et al.
Publicado: (2015)

A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder
por: Loureiro, Livia O., et al.
Publicado: (2021)

Neuromotor Development in the Shank3 Mouse Model of Autism Spectrum Disorder
por: Pillerová, Miriam, et al.
Publicado: (2022)

SHANK2 mutations associated with Autism Spectrum Disorder cause hyperconnectivity of human neurons
por: Zaslavsky, Kirill, et al.
Publicado: (2019)

Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain
por: Kim, Hyopil, et al.
Publicado: (2018)

Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene
por: Ma, Suk-Ling, et al.
Publicado: (2021)

Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits
por: Kozol, Robert A., et al.
Publicado: (2021)

Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice
por: Vyas, Yukti, et al.
Publicado: (2020)

Shank2 Regulates Renal Albumin Endocytosis
por: Dobrinskikh, Evgenia, et al.
Publicado: (2015)

Transcription-independent expression of PKMζ in the anterior cingulate cortex contributes to chronically maintained neuropathic pain
por: Ko, Hyoung-Gon, et al.
Publicado: (2018)

Effect of Early Swimming on the Behavior and Striatal Transcriptome of the Shank3 Knockout Rat Model of Autism
por: Meng, Yunchen, et al.
Publicado: (2022)

Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation
por: Hwang, Su-Kyeong, et al.
Publicado: (2016)

Effect of Calcium Lactate on Physico-Chemical Characteristics of Shank Bone Extract
por: Choi, Jung-Seok, et al.
Publicado: (2017)

Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism
por: James, David M., et al.
Publicado: (2019)

Spatial Learning and Motor Deficits in Vacuolar Protein Sorting-associated Protein 13b (Vps13b) Mutant Mouse
por: Kim, Min Jung, et al.
Publicado: (2019)

Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders
por: Garrido, Débora, et al.
Publicado: (2022)

William Frederick Shanks
Publicado: (1926)

Rare SHANK2 variants in schizophrenia
por: Peykov, S, et al.
Publicado: (2015)

Targeting Shank3 deficiency and paresthesia in autism spectrum disorder: A brief review
por: Huang, Min, et al.
Publicado: (2023)

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
por: Lee, Yeunkum, et al.
Publicado: (2017)

In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons
por: Vyas, Yukti, et al.
Publicado: (2021)

Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
por: Park, Jihye, et al.
Publicado: (2015)

Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons
por: Jin, Chunmei, et al.
Publicado: (2019)

Expression profiles of the autism-related SHANK proteins in the human brain
por: Woelfle, Sarah, et al.
Publicado: (2023)

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders
por: Leblond, Claire S., et al.
Publicado: (2012)

Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology
por: Berkel, Simone, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kumvsh6v5b2otev8t210mgunjs