TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies

Patients with mutated TP53 have been identified as having comparatively poor outcomes compared to those retaining wild-type p53 in many cancers, including squamous cell carcinomas of the head and neck (SCCHN). We have examined the role of p53 in regulation of metabolism in SCCHN cells and find that...

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Detalles Bibliográficos
Autores principales: Wilkie, Mark D., Anaam, Emad A., Lau, Andrew S., Rubbi, Carlos P., Jones, Terence M., Boyd, Mark T., Vlatković, Nikolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133053/
https://www.ncbi.nlm.nih.gov/pubmed/32113989
http://dx.doi.org/10.1016/j.canlet.2020.02.032

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