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Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft()
OBJECTIVES: To evaluate ureteral replacement by a free homologous graft of acellular matrix in a rat model. METHODS: In 30 male Sprague-Dawley rats, a 0.3 to 0.8-cm midsegment of the left ureter was resected and replaced with an acellular matrix graft of equal length placed on a polyethylene stent....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133180/ https://www.ncbi.nlm.nih.gov/pubmed/9372902 http://dx.doi.org/10.1016/S0090-4295(97)00391-9 |
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author | Dahms, Stefan E. Piechota, Hans J. Nunes, Lora Dahiya, Rajvir Lue, Tom F. Tanagho, Emil A. |
author_facet | Dahms, Stefan E. Piechota, Hans J. Nunes, Lora Dahiya, Rajvir Lue, Tom F. Tanagho, Emil A. |
author_sort | Dahms, Stefan E. |
collection | PubMed |
description | OBJECTIVES: To evaluate ureteral replacement by a free homologous graft of acellular matrix in a rat model. METHODS: In 30 male Sprague-Dawley rats, a 0.3 to 0.8-cm midsegment of the left ureter was resected and replaced with an acellular matrix graft of equal length placed on a polyethylene stent. The animals were killed at varying intervals, and the grafted specimens were prepared for light and electron microscopy. RESULTS: In all animals, the acellular matrix graft remained in its original position without evidence of incrustation or infection, and histologic examination showed complete epithelialization and progressive infiltration by vessels. At 10 weeks, smooth muscle fibers were observed; at 12 weeks, nerve fibers were first detected; at 4 months, smooth muscle cells had assumed regular configuration. CONCLUSIONS: The ureteral acellular matrix graft appears to promote the regeneration of all ureteral wall components. |
format | Online Article Text |
id | pubmed-7133180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71331802020-04-08 Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() Dahms, Stefan E. Piechota, Hans J. Nunes, Lora Dahiya, Rajvir Lue, Tom F. Tanagho, Emil A. Urology Article OBJECTIVES: To evaluate ureteral replacement by a free homologous graft of acellular matrix in a rat model. METHODS: In 30 male Sprague-Dawley rats, a 0.3 to 0.8-cm midsegment of the left ureter was resected and replaced with an acellular matrix graft of equal length placed on a polyethylene stent. The animals were killed at varying intervals, and the grafted specimens were prepared for light and electron microscopy. RESULTS: In all animals, the acellular matrix graft remained in its original position without evidence of incrustation or infection, and histologic examination showed complete epithelialization and progressive infiltration by vessels. At 10 weeks, smooth muscle fibers were observed; at 12 weeks, nerve fibers were first detected; at 4 months, smooth muscle cells had assumed regular configuration. CONCLUSIONS: The ureteral acellular matrix graft appears to promote the regeneration of all ureteral wall components. Published by Elsevier Inc. 1997-11 2001-01-15 /pmc/articles/PMC7133180/ /pubmed/9372902 http://dx.doi.org/10.1016/S0090-4295(97)00391-9 Text en Copyright © 1997 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Dahms, Stefan E. Piechota, Hans J. Nunes, Lora Dahiya, Rajvir Lue, Tom F. Tanagho, Emil A. Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title | Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title_full | Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title_fullStr | Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title_full_unstemmed | Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title_short | Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
title_sort | free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133180/ https://www.ncbi.nlm.nih.gov/pubmed/9372902 http://dx.doi.org/10.1016/S0090-4295(97)00391-9 |
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