Protease-dependent virus tropism and pathogenicity

Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the...

Descripción completa

Detalles Bibliográficos
Autor principal: Nagai, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133224/
https://www.ncbi.nlm.nih.gov/pubmed/8143121
http://dx.doi.org/10.1016/0966-842X(93)90112-5
_version_ 1783517584774135808
author Nagai, Yoshiyuki
author_facet Nagai, Yoshiyuki
author_sort Nagai, Yoshiyuki
collection PubMed
description Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.
format Online
Article
Text
id pubmed-7133224
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71332242020-04-08 Protease-dependent virus tropism and pathogenicity Nagai, Yoshiyuki Trends Microbiol Article Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins. Published by Elsevier Ltd. 1993-06 2003-06-18 /pmc/articles/PMC7133224/ /pubmed/8143121 http://dx.doi.org/10.1016/0966-842X(93)90112-5 Text en Copyright © 1993 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nagai, Yoshiyuki
Protease-dependent virus tropism and pathogenicity
title Protease-dependent virus tropism and pathogenicity
title_full Protease-dependent virus tropism and pathogenicity
title_fullStr Protease-dependent virus tropism and pathogenicity
title_full_unstemmed Protease-dependent virus tropism and pathogenicity
title_short Protease-dependent virus tropism and pathogenicity
title_sort protease-dependent virus tropism and pathogenicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133224/
https://www.ncbi.nlm.nih.gov/pubmed/8143121
http://dx.doi.org/10.1016/0966-842X(93)90112-5
work_keys_str_mv AT nagaiyoshiyuki proteasedependentvirustropismandpathogenicity

Ejemplares similares