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Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of...

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Detalles Bibliográficos
Autores principales: Slifka, Mark K., Ahmed, Rafi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133309/
https://www.ncbi.nlm.nih.gov/pubmed/8899965
http://dx.doi.org/10.1016/0966-842X(96)10059-7
Descripción
Sumario:Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.