Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of...

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Detalles Bibliográficos
Autores principales: Slifka, Mark K., Ahmed, Rafi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133309/
https://www.ncbi.nlm.nih.gov/pubmed/8899965
http://dx.doi.org/10.1016/0966-842X(96)10059-7
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author Slifka, Mark K.
Ahmed, Rafi
author_facet Slifka, Mark K.
Ahmed, Rafi
author_sort Slifka, Mark K.
collection PubMed
description Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.
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spelling pubmed-71333092020-04-08 Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity Slifka, Mark K. Ahmed, Rafi Trends Microbiol Article Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity. Published by Elsevier Ltd. 1996-10 1999-03-19 /pmc/articles/PMC7133309/ /pubmed/8899965 http://dx.doi.org/10.1016/0966-842X(96)10059-7 Text en Copyright © 1996 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Slifka, Mark K.
Ahmed, Rafi
Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title_full Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title_fullStr Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title_full_unstemmed Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title_short Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
title_sort long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133309/
https://www.ncbi.nlm.nih.gov/pubmed/8899965
http://dx.doi.org/10.1016/0966-842X(96)10059-7
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