Coronavirus infection of polarized epithelial cells

Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for t...

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Detalles Bibliográficos
Autores principales: Rossen, John W.A, Horzinek, Marian C, Rottler, Peter J.M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1995
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133323/
https://www.ncbi.nlm.nih.gov/pubmed/8800844
http://dx.doi.org/10.1016/S0966-842X(00)89018-6
Descripción
Sumario:Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins.

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