Coronavirus infection of polarized epithelial cells

Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for t...

Descripción completa

Detalles Bibliográficos
Autores principales: Rossen, John W.A, Horzinek, Marian C, Rottler, Peter J.M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1995
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133323/
https://www.ncbi.nlm.nih.gov/pubmed/8800844
http://dx.doi.org/10.1016/S0966-842X(00)89018-6
_version_ 1783517607572275200
author Rossen, John W.A
Horzinek, Marian C
Rottler, Peter J.M
author_facet Rossen, John W.A
Horzinek, Marian C
Rottler, Peter J.M
author_sort Rossen, John W.A
collection PubMed
description Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins.
format Online
Article
Text
id pubmed-7133323
institution National Center for Biotechnology Information
language English
publishDate 1995
publisher Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71333232020-04-08 Coronavirus infection of polarized epithelial cells Rossen, John W.A Horzinek, Marian C Rottler, Peter J.M Trends Microbiol Opinion Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins. Published by Elsevier Ltd. 1995-12 2000-08-01 /pmc/articles/PMC7133323/ /pubmed/8800844 http://dx.doi.org/10.1016/S0966-842X(00)89018-6 Text en Copyright © 1995 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinion
Rossen, John W.A
Horzinek, Marian C
Rottler, Peter J.M
Coronavirus infection of polarized epithelial cells
title Coronavirus infection of polarized epithelial cells
title_full Coronavirus infection of polarized epithelial cells
title_fullStr Coronavirus infection of polarized epithelial cells
title_full_unstemmed Coronavirus infection of polarized epithelial cells
title_short Coronavirus infection of polarized epithelial cells
title_sort coronavirus infection of polarized epithelial cells
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133323/
https://www.ncbi.nlm.nih.gov/pubmed/8800844
http://dx.doi.org/10.1016/S0966-842X(00)89018-6
work_keys_str_mv AT rossenjohnwa coronavirusinfectionofpolarizedepithelialcells
AT horzinekmarianc coronavirusinfectionofpolarizedepithelialcells
AT rottlerpeterjm coronavirusinfectionofpolarizedepithelialcells

Ejemplares similares