The effect of endometrial injury on reproductive outcomes of frozen–thawed embryo transfer cycles in women with one implantation failure

OBJECTIVE: Endometrial injury (EI) is a simple procedure that may improve endometrial receptivity. The purpose of our study was to investigate whether EI improves reproductive outcomes of frozen-thawed embryo transfer (FET) cycles in patients with one implantation failure. METHODS: The EI group comprised 258 selected patients, and the control group comprised 258 patients retrospectively matched by age, number of transferred embryos, and stage of transferred embryos. The EI group underwent EI in the proliferative phase of FET cycles, and the control group did not undergo EI. The primary outcome was clinical pregnancy rate. RESULTS: We detected significant differences between the EI and control groups in rates of biochemical pregnancy (5.0% vs. 10.1%), implantation (31.7% vs. 25.3%), clinical pregnancy (47.3% vs. 37.6%), and live birth (39.1% vs. 30.2%). Moreover, EI was found to be an independent factor that affected clinical pregnancy rate, as assessed by logistic regression analysis. CONCLUSION: EI in the proliferative phase of FET cycles improves rates of implantation, clinical pregnancy, and live birth in women with one implantation failure.