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Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report

The present study reports a rare case of a 65-year-old male patient with an exophytic ulcerative lesion in the gastric antrum. After performing a radical subtotal gastrectomy with D2 lymph node dissection and Billroth I gastrojejunostomy, histological analysis revealed a poorly differentiated adenoc...

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Autores principales: Chen, Lei, Yi, Xin, Zou, Hong-Li, Chen, Xu-An, Gao, Shang, Zhang, Pei-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133413/
https://www.ncbi.nlm.nih.gov/pubmed/32216498
http://dx.doi.org/10.1177/0300060520904876
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author Chen, Lei
Yi, Xin
Zou, Hong-Li
Chen, Xu-An
Gao, Shang
Zhang, Pei-Hai
author_facet Chen, Lei
Yi, Xin
Zou, Hong-Li
Chen, Xu-An
Gao, Shang
Zhang, Pei-Hai
author_sort Chen, Lei
collection PubMed
description The present study reports a rare case of a 65-year-old male patient with an exophytic ulcerative lesion in the gastric antrum. After performing a radical subtotal gastrectomy with D2 lymph node dissection and Billroth I gastrojejunostomy, histological analysis revealed a poorly differentiated adenocarcinoma combined with a biphasic pattern consisting of cytotrophoblasts and syncytiotrophoblasts. Immunohistochemical analysis showed a positive reaction with an anti-β-human chorionic gonadotropin antibody, and an abnormal increase in reproductive hormones. Furthermore, the patient succumbed to upper gastrointestinal hemorrhage in less than 3 months after the initial diagnosis, although the rupture of his liver metastasis was successfully treated by transhepatic artery embolization during the second admission.
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spelling pubmed-71334132020-04-13 Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report Chen, Lei Yi, Xin Zou, Hong-Li Chen, Xu-An Gao, Shang Zhang, Pei-Hai J Int Med Res Case Report The present study reports a rare case of a 65-year-old male patient with an exophytic ulcerative lesion in the gastric antrum. After performing a radical subtotal gastrectomy with D2 lymph node dissection and Billroth I gastrojejunostomy, histological analysis revealed a poorly differentiated adenocarcinoma combined with a biphasic pattern consisting of cytotrophoblasts and syncytiotrophoblasts. Immunohistochemical analysis showed a positive reaction with an anti-β-human chorionic gonadotropin antibody, and an abnormal increase in reproductive hormones. Furthermore, the patient succumbed to upper gastrointestinal hemorrhage in less than 3 months after the initial diagnosis, although the rupture of his liver metastasis was successfully treated by transhepatic artery embolization during the second admission. SAGE Publications 2020-03-27 /pmc/articles/PMC7133413/ /pubmed/32216498 http://dx.doi.org/10.1177/0300060520904876 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Chen, Lei
Yi, Xin
Zou, Hong-Li
Chen, Xu-An
Gao, Shang
Zhang, Pei-Hai
Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title_full Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title_fullStr Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title_full_unstemmed Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title_short Coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
title_sort coexistence of gastric choriocarcinoma and adenocarcinoma with reproductive hormone secretion in a man: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133413/
https://www.ncbi.nlm.nih.gov/pubmed/32216498
http://dx.doi.org/10.1177/0300060520904876
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