Elevation of the unfolded protein response increases RANKL expression

Increased production of the osteoclastogenic cytokine RANKL is a common feature of pathologic bone loss, but the underlying cause of this increase is poorly understood. The unfolded protein response (UPR) is activated in response to accumulation of misfolded proteins in the endoplasmic reticulum (ER...

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Detalles Bibliográficos
Autores principales: Iyer, Srividhya, Melendez‐Suchi, Christian, Han, Li, Baldini, Giulia, Almeida, Maria, Jilka, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133738/
https://www.ncbi.nlm.nih.gov/pubmed/32259048
http://dx.doi.org/10.1096/fba.2019-00032

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