Mechanism of action of the antiviral compound MDL 20,610

The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56°C) and low pH (5.0) inactiv...

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Detalles Bibliográficos
Autores principales: Kenny, Michael T., Torney, Harry L., Dulworth, Jacqueline K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133839/
https://www.ncbi.nlm.nih.gov/pubmed/2849377
http://dx.doi.org/10.1016/0166-3542(88)90056-3
Descripción
Sumario:The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56°C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.

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