Mechanism of action of the antiviral compound MDL 20,610

The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56°C) and low pH (5.0) inactiv...

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Detalles Bibliográficos
Autores principales: Kenny, Michael T., Torney, Harry L., Dulworth, Jacqueline K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133839/
https://www.ncbi.nlm.nih.gov/pubmed/2849377
http://dx.doi.org/10.1016/0166-3542(88)90056-3
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author Kenny, Michael T.
Torney, Harry L.
Dulworth, Jacqueline K.
author_facet Kenny, Michael T.
Torney, Harry L.
Dulworth, Jacqueline K.
author_sort Kenny, Michael T.
collection PubMed
description The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56°C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating.
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spelling pubmed-71338392020-04-08 Mechanism of action of the antiviral compound MDL 20,610 Kenny, Michael T. Torney, Harry L. Dulworth, Jacqueline K. Antiviral Res Article The purpose of this study was to probe the antirhinovirus (RV) mechanism of action of MDL 20,610. Evaluation of the compound's effects on RV RNA synthesis, uncoating of neutral red-sensitized RV, plasma membrane penetration by RV, stabilization of RV against heat (56°C) and low pH (5.0) inactivation, and studies with MDL 20,610-resistant RV mutants indicate that MDL 20,610 binds directly to the RV capsid with subsequent inhibition of acid-mediated virion uncoating. Published by Elsevier B.V. 1988-07 2002-11-12 /pmc/articles/PMC7133839/ /pubmed/2849377 http://dx.doi.org/10.1016/0166-3542(88)90056-3 Text en Copyright © 1988 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kenny, Michael T.
Torney, Harry L.
Dulworth, Jacqueline K.
Mechanism of action of the antiviral compound MDL 20,610
title Mechanism of action of the antiviral compound MDL 20,610
title_full Mechanism of action of the antiviral compound MDL 20,610
title_fullStr Mechanism of action of the antiviral compound MDL 20,610
title_full_unstemmed Mechanism of action of the antiviral compound MDL 20,610
title_short Mechanism of action of the antiviral compound MDL 20,610
title_sort mechanism of action of the antiviral compound mdl 20,610
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133839/
https://www.ncbi.nlm.nih.gov/pubmed/2849377
http://dx.doi.org/10.1016/0166-3542(88)90056-3
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