The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers

In a double-blind, placebo-controlled study, self-administered intranasal interferonα-2a or placebo was given both before and after challenge with respiratory syncytial virus. The incidence of colds and the severity of signs and symptoms were reduced in those receiving interferonα-2a as compared wit...

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Detalles Bibliográficos
Autores principales: Higgins, P.G., Barrow, G.I., Tyrrell, D.A.J., Isaacs, D., Gauci, C.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134029/
https://www.ncbi.nlm.nih.gov/pubmed/2080867
http://dx.doi.org/10.1016/0166-3542(90)90061-B
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author Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
Isaacs, D.
Gauci, C.L.
author_facet Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
Isaacs, D.
Gauci, C.L.
author_sort Higgins, P.G.
collection PubMed
description In a double-blind, placebo-controlled study, self-administered intranasal interferonα-2a or placebo was given both before and after challenge with respiratory syncytial virus. The incidence of colds and the severity of signs and symptoms were reduced in those receiving interferonα-2a as compared with those given placebo. In a further double-blind, placebo-controlled study, self-administered interferonα-2a or placebo was given only to those volunteers who developed colds following challenge with respiratory syncytial virus. There was no evidence that interferonα-2a reduced the severity of the signs and symptoms or shortened the duration of the illness. The similarity of these results to the effect of interferonα-2a in rhinovirus infections in volunteers is discussed.
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spelling pubmed-71340292020-04-08 The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers Higgins, P.G. Barrow, G.I. Tyrrell, D.A.J. Isaacs, D. Gauci, C.L. Antiviral Res Article In a double-blind, placebo-controlled study, self-administered intranasal interferonα-2a or placebo was given both before and after challenge with respiratory syncytial virus. The incidence of colds and the severity of signs and symptoms were reduced in those receiving interferonα-2a as compared with those given placebo. In a further double-blind, placebo-controlled study, self-administered interferonα-2a or placebo was given only to those volunteers who developed colds following challenge with respiratory syncytial virus. There was no evidence that interferonα-2a reduced the severity of the signs and symptoms or shortened the duration of the illness. The similarity of these results to the effect of interferonα-2a in rhinovirus infections in volunteers is discussed. Published by Elsevier B.V. 1990-07 2002-11-14 /pmc/articles/PMC7134029/ /pubmed/2080867 http://dx.doi.org/10.1016/0166-3542(90)90061-B Text en Copyright © 1990 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Higgins, P.G.
Barrow, G.I.
Tyrrell, D.A.J.
Isaacs, D.
Gauci, C.L.
The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title_full The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title_fullStr The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title_full_unstemmed The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title_short The efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
title_sort efficacy of intranasal interferonα-2a in respiratory syncytial virus infection in volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134029/
https://www.ncbi.nlm.nih.gov/pubmed/2080867
http://dx.doi.org/10.1016/0166-3542(90)90061-B
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