Non-linear Dynamics of Two-Patch Model Incorporating Secondary Dengue Infection

In this paper, the impact of human migration on the dynamics of dengue epidemic has been discussed. The vector-host model considers two patches with different dengue serotype in each patch. The model considers the constant rate of migration in susceptible and recovered class from one patch to other. Recovered migrants from prior infection are exposed to secondary infection in the patch where different serotype is present. The basic reproduction number is computed and analyzed in terms of migration parameters. The model is analyzed for the existence and local stability of various equilibrium states in terms of migration parameters. The numerical simulations for the choice of relevant data from literature have been performed to verify analytical results and to further explore the dynamics of the system. The sensitivity analysis of basic reproduction number with respect to migration parameters is carried out. It is found that immigration in a patch increases the basic reproduction in respective patch and vice-versa. The basic reproduction number has been estimated for the two states of Brazil which verifies the occurrence of severe epidemic in one of the states of Brazil.