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Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS:...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade de Medicina / USP
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134550/ https://www.ncbi.nlm.nih.gov/pubmed/32294671 http://dx.doi.org/10.6061/clinics/2020/e1588 |
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author | Pajecki, Denis Kawamoto, Flavio Dantas, Anna Carolina Batista Andrade, Priscila Caldeira Brasil, Nissia Capello Junqueira, Silvio Mauro de Oliveira, Fernanda Maria Pirozelli Ribeiro, Rodrigo Antonini Santo, Marco Aurelio |
author_facet | Pajecki, Denis Kawamoto, Flavio Dantas, Anna Carolina Batista Andrade, Priscila Caldeira Brasil, Nissia Capello Junqueira, Silvio Mauro de Oliveira, Fernanda Maria Pirozelli Ribeiro, Rodrigo Antonini Santo, Marco Aurelio |
author_sort | Pajecki, Denis |
collection | PubMed |
description | OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS: A retrospective, single center study was conducted to collect real-world evidence of health outcomes and medication use in 247 obese patients (female, 82.2%) who underwent open Roux-en-Y gastric bypass. Changes in weight and body mass index (BMI), presence of apnea, hypertension, and type 2 diabetes (T2D), and medication use (hypertension, diabetes, and dyslipidemia) were assessed preoperatively and up to 24 months postoperatively. The mean cost of medications was calculated for the 12-month preoperative and 24-month postoperative periods. RESULTS: During the surgery, the mean age of patients was 43.42 years (standard deviation [SD], 10.9 years), and mean BMI was 46.7 kg/m(2) (SD, 6.7 kg/m(2)). At 24 months, significant declines were noted in weight (mean, -37.6 kg), BMI (mean, -14.3 kg/m(2)); presence of T2D, hypertension, and apnea (-29.6%, -50.6%, and -20.9%, respectively); and number of patients using medications (-66.67% for diabetes, -41.86% for hypertension, and -55.26% for dyslipidemia). The mean cost of medications (total costs for all medications) decreased by >50% in 12–24 postoperative months compared to that in 12 preoperative months. CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System. |
format | Online Article Text |
id | pubmed-7134550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Faculdade de Medicina / USP |
record_format | MEDLINE/PubMed |
spelling | pubmed-71345502020-04-10 Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study Pajecki, Denis Kawamoto, Flavio Dantas, Anna Carolina Batista Andrade, Priscila Caldeira Brasil, Nissia Capello Junqueira, Silvio Mauro de Oliveira, Fernanda Maria Pirozelli Ribeiro, Rodrigo Antonini Santo, Marco Aurelio Clinics (Sao Paulo) Original Article OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS: A retrospective, single center study was conducted to collect real-world evidence of health outcomes and medication use in 247 obese patients (female, 82.2%) who underwent open Roux-en-Y gastric bypass. Changes in weight and body mass index (BMI), presence of apnea, hypertension, and type 2 diabetes (T2D), and medication use (hypertension, diabetes, and dyslipidemia) were assessed preoperatively and up to 24 months postoperatively. The mean cost of medications was calculated for the 12-month preoperative and 24-month postoperative periods. RESULTS: During the surgery, the mean age of patients was 43.42 years (standard deviation [SD], 10.9 years), and mean BMI was 46.7 kg/m(2) (SD, 6.7 kg/m(2)). At 24 months, significant declines were noted in weight (mean, -37.6 kg), BMI (mean, -14.3 kg/m(2)); presence of T2D, hypertension, and apnea (-29.6%, -50.6%, and -20.9%, respectively); and number of patients using medications (-66.67% for diabetes, -41.86% for hypertension, and -55.26% for dyslipidemia). The mean cost of medications (total costs for all medications) decreased by >50% in 12–24 postoperative months compared to that in 12 preoperative months. CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System. Faculdade de Medicina / USP 2020-04-06 2020 /pmc/articles/PMC7134550/ /pubmed/32294671 http://dx.doi.org/10.6061/clinics/2020/e1588 Text en Copyright © 2020 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. |
spellingShingle | Original Article Pajecki, Denis Kawamoto, Flavio Dantas, Anna Carolina Batista Andrade, Priscila Caldeira Brasil, Nissia Capello Junqueira, Silvio Mauro de Oliveira, Fernanda Maria Pirozelli Ribeiro, Rodrigo Antonini Santo, Marco Aurelio Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title | Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title_full | Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title_fullStr | Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title_full_unstemmed | Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title_short | Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study |
title_sort | real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in brazil: a retrospective, single-center study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134550/ https://www.ncbi.nlm.nih.gov/pubmed/32294671 http://dx.doi.org/10.6061/clinics/2020/e1588 |
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