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Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study

OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS:...

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Autores principales: Pajecki, Denis, Kawamoto, Flavio, Dantas, Anna Carolina Batista, Andrade, Priscila Caldeira, Brasil, Nissia Capello, Junqueira, Silvio Mauro, de Oliveira, Fernanda Maria Pirozelli, Ribeiro, Rodrigo Antonini, Santo, Marco Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Medicina / USP 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134550/
https://www.ncbi.nlm.nih.gov/pubmed/32294671
http://dx.doi.org/10.6061/clinics/2020/e1588
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author Pajecki, Denis
Kawamoto, Flavio
Dantas, Anna Carolina Batista
Andrade, Priscila Caldeira
Brasil, Nissia Capello
Junqueira, Silvio Mauro
de Oliveira, Fernanda Maria Pirozelli
Ribeiro, Rodrigo Antonini
Santo, Marco Aurelio
author_facet Pajecki, Denis
Kawamoto, Flavio
Dantas, Anna Carolina Batista
Andrade, Priscila Caldeira
Brasil, Nissia Capello
Junqueira, Silvio Mauro
de Oliveira, Fernanda Maria Pirozelli
Ribeiro, Rodrigo Antonini
Santo, Marco Aurelio
author_sort Pajecki, Denis
collection PubMed
description OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS: A retrospective, single center study was conducted to collect real-world evidence of health outcomes and medication use in 247 obese patients (female, 82.2%) who underwent open Roux-en-Y gastric bypass. Changes in weight and body mass index (BMI), presence of apnea, hypertension, and type 2 diabetes (T2D), and medication use (hypertension, diabetes, and dyslipidemia) were assessed preoperatively and up to 24 months postoperatively. The mean cost of medications was calculated for the 12-month preoperative and 24-month postoperative periods. RESULTS: During the surgery, the mean age of patients was 43.42 years (standard deviation [SD], 10.9 years), and mean BMI was 46.7 kg/m(2) (SD, 6.7 kg/m(2)). At 24 months, significant declines were noted in weight (mean, -37.6 kg), BMI (mean, -14.3 kg/m(2)); presence of T2D, hypertension, and apnea (-29.6%, -50.6%, and -20.9%, respectively); and number of patients using medications (-66.67% for diabetes, -41.86% for hypertension, and -55.26% for dyslipidemia). The mean cost of medications (total costs for all medications) decreased by >50% in 12–24 postoperative months compared to that in 12 preoperative months. CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System.
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spelling pubmed-71345502020-04-10 Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study Pajecki, Denis Kawamoto, Flavio Dantas, Anna Carolina Batista Andrade, Priscila Caldeira Brasil, Nissia Capello Junqueira, Silvio Mauro de Oliveira, Fernanda Maria Pirozelli Ribeiro, Rodrigo Antonini Santo, Marco Aurelio Clinics (Sao Paulo) Original Article OBJECTIVES: The number of bariatric procedures has significantly increased in Brazil, especially in the public Unified Health System. The present study describes health outcomes and medication use in obese patients treated in a major hospital that performs publicly funded surgery in Brazil. METHODS: A retrospective, single center study was conducted to collect real-world evidence of health outcomes and medication use in 247 obese patients (female, 82.2%) who underwent open Roux-en-Y gastric bypass. Changes in weight and body mass index (BMI), presence of apnea, hypertension, and type 2 diabetes (T2D), and medication use (hypertension, diabetes, and dyslipidemia) were assessed preoperatively and up to 24 months postoperatively. The mean cost of medications was calculated for the 12-month preoperative and 24-month postoperative periods. RESULTS: During the surgery, the mean age of patients was 43.42 years (standard deviation [SD], 10.9 years), and mean BMI was 46.7 kg/m(2) (SD, 6.7 kg/m(2)). At 24 months, significant declines were noted in weight (mean, -37.6 kg), BMI (mean, -14.3 kg/m(2)); presence of T2D, hypertension, and apnea (-29.6%, -50.6%, and -20.9%, respectively); and number of patients using medications (-66.67% for diabetes, -41.86% for hypertension, and -55.26% for dyslipidemia). The mean cost of medications (total costs for all medications) decreased by >50% in 12–24 postoperative months compared to that in 12 preoperative months. CONCLUSION: Roux-en-Y gastric bypass successfully reduced weight, BMI, and comorbidities and medication use and cost at 24 months in Brazilian patients treated in the public Unified Health System. Faculdade de Medicina / USP 2020-04-06 2020 /pmc/articles/PMC7134550/ /pubmed/32294671 http://dx.doi.org/10.6061/clinics/2020/e1588 Text en Copyright © 2020 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Pajecki, Denis
Kawamoto, Flavio
Dantas, Anna Carolina Batista
Andrade, Priscila Caldeira
Brasil, Nissia Capello
Junqueira, Silvio Mauro
de Oliveira, Fernanda Maria Pirozelli
Ribeiro, Rodrigo Antonini
Santo, Marco Aurelio
Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title_full Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title_fullStr Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title_full_unstemmed Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title_short Real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in Brazil: a retrospective, single-center study
title_sort real-world evidence of health outcomes and medication use 24 months after bariatric surgery in the public healthcare system in brazil: a retrospective, single-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134550/
https://www.ncbi.nlm.nih.gov/pubmed/32294671
http://dx.doi.org/10.6061/clinics/2020/e1588
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