BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS

Cultures of an isolate of Penicillium verrucosum var. cyclopium, obtained from stored maize in an area of Balkan (endemic) nephropathy—Vratza, Bulgaria—has consistently induced renal tubular lesions when force-fed to rats for 20 days. The lesions, confined to the lower reaches of the proximal convol...

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Detalles Bibliográficos
Autores principales: Barnes, J.M., Carter, R.L., Peristianis, G.C., Austwick, P.K.C., Flynn, F.V., Aldridge, W.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1977
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134643/
https://www.ncbi.nlm.nih.gov/pubmed/66474
http://dx.doi.org/10.1016/S0140-6736(77)92115-8
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author Barnes, J.M.
Carter, R.L.
Peristianis, G.C.
Austwick, P.K.C.
Flynn, F.V.
Aldridge, W.N.
author_facet Barnes, J.M.
Carter, R.L.
Peristianis, G.C.
Austwick, P.K.C.
Flynn, F.V.
Aldridge, W.N.
author_sort Barnes, J.M.
collection PubMed
description Cultures of an isolate of Penicillium verrucosum var. cyclopium, obtained from stored maize in an area of Balkan (endemic) nephropathy—Vratza, Bulgaria—has consistently induced renal tubular lesions when force-fed to rats for 20 days. The lesions, confined to the lower reaches of the proximal convoluted tubules (pars recta and junctional zone), closely resemble the tubular changes in patients with Balkan nephropathy. Preliminary evidence suggests that this nephrotoxin-producing strain of P. verrucosum var. cyclopium may be implicated in the ætiology of Balkan nephropathy.
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spelling pubmed-71346432020-04-08 BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS Barnes, J.M. Carter, R.L. Peristianis, G.C. Austwick, P.K.C. Flynn, F.V. Aldridge, W.N. Lancet Article Cultures of an isolate of Penicillium verrucosum var. cyclopium, obtained from stored maize in an area of Balkan (endemic) nephropathy—Vratza, Bulgaria—has consistently induced renal tubular lesions when force-fed to rats for 20 days. The lesions, confined to the lower reaches of the proximal convoluted tubules (pars recta and junctional zone), closely resemble the tubular changes in patients with Balkan nephropathy. Preliminary evidence suggests that this nephrotoxin-producing strain of P. verrucosum var. cyclopium may be implicated in the ætiology of Balkan nephropathy. Published by Elsevier Ltd. 1977-03-26 2003-08-22 /pmc/articles/PMC7134643/ /pubmed/66474 http://dx.doi.org/10.1016/S0140-6736(77)92115-8 Text en Copyright © 1977 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Barnes, J.M.
Carter, R.L.
Peristianis, G.C.
Austwick, P.K.C.
Flynn, F.V.
Aldridge, W.N.
BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title_full BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title_fullStr BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title_full_unstemmed BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title_short BALKAN (ENDEMIC) NEPHROPATHY AND A TOXIN-PRODUCING STRAIN OF PENICILLIUM VERRUCOSUM VAR CYCLOPIUM: AN EXPERIMENTAL MODEL IN RATS
title_sort balkan (endemic) nephropathy and a toxin-producing strain of penicillium verrucosum var cyclopium: an experimental model in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134643/
https://www.ncbi.nlm.nih.gov/pubmed/66474
http://dx.doi.org/10.1016/S0140-6736(77)92115-8
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