Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus

Successful recovery of RNA viruses and functional RNA replicons from cDNA has greatly facilitated molecular genetic analyses of viral proteins and cis-regulatory elements. This technology allows the use of RNA virus replication machinery to express heterologous sequences. Both positive-strand and ne...

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Detalles Bibliográficos
Autor principal: Rice, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134803/
https://www.ncbi.nlm.nih.gov/pubmed/1369402
http://dx.doi.org/10.1016/0958-1669(92)90081-S
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author Rice, Charles M.
author_facet Rice, Charles M.
author_sort Rice, Charles M.
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description Successful recovery of RNA viruses and functional RNA replicons from cDNA has greatly facilitated molecular genetic analyses of viral proteins and cis-regulatory elements. This technology allows the use of RNA virus replication machinery to express heterologous sequences. Both positive-strand and negative-strand animal RNA viruses have been engineered to produce chimeric viruses expressing protective epitopes from other pathogens and for transient expression of heterologous sequences.
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spelling pubmed-71348032020-04-08 Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus Rice, Charles M. Curr Opin Biotechnol Article Successful recovery of RNA viruses and functional RNA replicons from cDNA has greatly facilitated molecular genetic analyses of viral proteins and cis-regulatory elements. This technology allows the use of RNA virus replication machinery to express heterologous sequences. Both positive-strand and negative-strand animal RNA viruses have been engineered to produce chimeric viruses expressing protective epitopes from other pathogens and for transient expression of heterologous sequences. Published by Elsevier Ltd. 1992-10 2004-08-26 /pmc/articles/PMC7134803/ /pubmed/1369402 http://dx.doi.org/10.1016/0958-1669(92)90081-S Text en Copyright © 1992 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rice, Charles M.
Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title_full Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title_fullStr Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title_full_unstemmed Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title_short Examples of expression systems based on animal RNA viruses: Alphaviruses and influenza virus
title_sort examples of expression systems based on animal rna viruses: alphaviruses and influenza virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134803/
https://www.ncbi.nlm.nih.gov/pubmed/1369402
http://dx.doi.org/10.1016/0958-1669(92)90081-S
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