Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions

The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains diffe...

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Detalles Bibliográficos
Autores principales: Ghirardi, Orlando, Cozzolino, Roberto, Guaraldi, Donatella, Giuliani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1995
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134852/
https://www.ncbi.nlm.nih.gov/pubmed/8557096
http://dx.doi.org/10.1016/0531-5565(95)00002-X
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author Ghirardi, Orlando
Cozzolino, Roberto
Guaraldi, Donatella
Giuliani, Alessandro
author_facet Ghirardi, Orlando
Cozzolino, Roberto
Guaraldi, Donatella
Giuliani, Alessandro
author_sort Ghirardi, Orlando
collection PubMed
description The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to highlight some limitations of the classical Gompertzian approach.
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spelling pubmed-71348522020-04-08 Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions Ghirardi, Orlando Cozzolino, Roberto Guaraldi, Donatella Giuliani, Alessandro Exp Gerontol Article The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to highlight some limitations of the classical Gompertzian approach. Published by Elsevier Inc. 1995 2000-02-17 /pmc/articles/PMC7134852/ /pubmed/8557096 http://dx.doi.org/10.1016/0531-5565(95)00002-X Text en Copyright © 1995 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ghirardi, Orlando
Cozzolino, Roberto
Guaraldi, Donatella
Giuliani, Alessandro
Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title_full Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title_fullStr Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title_full_unstemmed Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title_short Within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
title_sort within-and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134852/
https://www.ncbi.nlm.nih.gov/pubmed/8557096
http://dx.doi.org/10.1016/0531-5565(95)00002-X
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