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Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study

Background: Lowered yields of virus-induced interferon (IFN) by leukocyte cultures were previously suggested to be associated with recurrent respiratory infections in children (Pitkäranta et al. (1993) Clin. Diagn. Virol. 1, 101–108) Objectives: To investigate if the observed lowered IFN producing c...

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Autores principales: Pitkäranta, Anne, Karma, Pekka, Hovi, Tapani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134928/
https://www.ncbi.nlm.nih.gov/pubmed/15566885
http://dx.doi.org/10.1016/0928-0197(96)00207-3
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author Pitkäranta, Anne
Karma, Pekka
Hovi, Tapani
author_facet Pitkäranta, Anne
Karma, Pekka
Hovi, Tapani
author_sort Pitkäranta, Anne
collection PubMed
description Background: Lowered yields of virus-induced interferon (IFN) by leukocyte cultures were previously suggested to be associated with recurrent respiratory infections in children (Pitkäranta et al. (1993) Clin. Diagn. Virol. 1, 101–108) Objectives: To investigate if the observed lowered IFN producing capacity was secondary to the underlying disease and, consequently, would be normalized after recovery of the child from the chain of infections. Study design: Forty-eight 3–12-year-old children suffering from recurrent upper respiratory tract infections (acute otitis media included) were followed-up for 2 years. Their clinical condition and virus-induced interferon production in cultures of peripheral blood leukocytes were examined at the beginning and end of this period. Results: In 24 children the health improved strikingly during the follow-up, in 12 children a mild improvement took place, while 12 children remained constantly ill. IFN yields in cultures stimulated with corona- and respiratory syncytical viruses improved along with the clinical situation of the children. Parallel cultures induced with adeno-, influenza A or rhinoviruses did not show a similar correlation. Conclusion: These results suggest that the relationship between interferon production by leukocyte cultures and recurrent infections is complex and may be virus-specific.
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spelling pubmed-71349282020-04-08 Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study Pitkäranta, Anne Karma, Pekka Hovi, Tapani Clin Diagn Virol Article Background: Lowered yields of virus-induced interferon (IFN) by leukocyte cultures were previously suggested to be associated with recurrent respiratory infections in children (Pitkäranta et al. (1993) Clin. Diagn. Virol. 1, 101–108) Objectives: To investigate if the observed lowered IFN producing capacity was secondary to the underlying disease and, consequently, would be normalized after recovery of the child from the chain of infections. Study design: Forty-eight 3–12-year-old children suffering from recurrent upper respiratory tract infections (acute otitis media included) were followed-up for 2 years. Their clinical condition and virus-induced interferon production in cultures of peripheral blood leukocytes were examined at the beginning and end of this period. Results: In 24 children the health improved strikingly during the follow-up, in 12 children a mild improvement took place, while 12 children remained constantly ill. IFN yields in cultures stimulated with corona- and respiratory syncytical viruses improved along with the clinical situation of the children. Parallel cultures induced with adeno-, influenza A or rhinoviruses did not show a similar correlation. Conclusion: These results suggest that the relationship between interferon production by leukocyte cultures and recurrent infections is complex and may be virus-specific. Published by Elsevier B.V. 1996-06 1999-03-08 /pmc/articles/PMC7134928/ /pubmed/15566885 http://dx.doi.org/10.1016/0928-0197(96)00207-3 Text en Copyright © 1996 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pitkäranta, Anne
Karma, Pekka
Hovi, Tapani
Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title_full Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title_fullStr Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title_full_unstemmed Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title_short Virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. A follow-up study
title_sort virus-induced interferon production in leukocyte cultures from children with recurrent respiratory infections. a follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134928/
https://www.ncbi.nlm.nih.gov/pubmed/15566885
http://dx.doi.org/10.1016/0928-0197(96)00207-3
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