A role for CD8(+) T lymphocytes in the pathogenesis of AIDS

Experimental and clinical evidence is presented which supports the hypothesis that CD8(+) T lymphocytes aimed at suppressing HIV replication in infected CD4(+) T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4(+) T lymphocyte numbers. Possible model...

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Detalles Bibliográficos
Autor principal: Aranda-Anzaldo, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS 1991
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135057/
https://www.ncbi.nlm.nih.gov/pubmed/1687487
http://dx.doi.org/10.1016/0923-2494(91)90099-5
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author Aranda-Anzaldo, A.
author_facet Aranda-Anzaldo, A.
author_sort Aranda-Anzaldo, A.
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description Experimental and clinical evidence is presented which supports the hypothesis that CD8(+) T lymphocytes aimed at suppressing HIV replication in infected CD4(+) T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4(+) T lymphocyte numbers. Possible models to test this hypothesis are discussed.
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spelling pubmed-71350572020-04-08 A role for CD8(+) T lymphocytes in the pathogenesis of AIDS Aranda-Anzaldo, A. Res Immunol Article Experimental and clinical evidence is presented which supports the hypothesis that CD8(+) T lymphocytes aimed at suppressing HIV replication in infected CD4(+) T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4(+) T lymphocyte numbers. Possible models to test this hypothesis are discussed. Published by Elsevier Masson SAS 1991 2002-12-09 /pmc/articles/PMC7135057/ /pubmed/1687487 http://dx.doi.org/10.1016/0923-2494(91)90099-5 Text en Copyright © 1991 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Aranda-Anzaldo, A.
A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title_full A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title_fullStr A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title_full_unstemmed A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title_short A role for CD8(+) T lymphocytes in the pathogenesis of AIDS
title_sort role for cd8(+) t lymphocytes in the pathogenesis of aids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135057/
https://www.ncbi.nlm.nih.gov/pubmed/1687487
http://dx.doi.org/10.1016/0923-2494(91)90099-5
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