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Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells

BACKGROUND: Irinotecan (IRI) is considered an option for second-line treatment of advanced gastric cancer; however, acquired drug resistance currently limits its clinical application. Recently, many researchers have shown that autophagy plays a crucial role in the resistance of tumor cells to chemot...

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Detalles Bibliográficos
Autores principales:	Zhu, Qingyun, Guo, Yuehui, Chen, Shiwei, Fu, Daiquan, Li, Yanxiang, Li, Zhi, Ni, Caifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135144/ https://www.ncbi.nlm.nih.gov/pubmed/32308415 http://dx.doi.org/10.2147/OTT.S240803

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