Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD

IL-17A and IL-17F cytokines are important regulators of acute graft-versus-host-disease (GVHD). However, contrary effects of these cytokines in inflammatory diseases have been reported. To investigate the effects of donor-derived IL-17A and IL-17F on GVHD, we made use of single (Il17a(-/-) or Il17f(...

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Detalles Bibliográficos
Autores principales: Odak, Ivan, Depkat-Jakob, Alina, Beck, Maleen, Jarek, Michael, Yu, Yan, Seidler, Ursula, David, Sascha, Ganser, Arnold, Förster, Reinhold, Prinz, Immo, Koenecke, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135231/
https://www.ncbi.nlm.nih.gov/pubmed/32251446
http://dx.doi.org/10.1371/journal.pone.0231222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135231/
https://www.ncbi.nlm.nih.gov/pubmed/32251446
http://dx.doi.org/10.1371/journal.pone.0231222

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