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Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD

IL-17A and IL-17F cytokines are important regulators of acute graft-versus-host-disease (GVHD). However, contrary effects of these cytokines in inflammatory diseases have been reported. To investigate the effects of donor-derived IL-17A and IL-17F on GVHD, we made use of single (Il17a(-/-) or Il17f(...

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Detalles Bibliográficos
Autores principales:	Odak, Ivan, Depkat-Jakob, Alina, Beck, Maleen, Jarek, Michael, Yu, Yan, Seidler, Ursula, David, Sascha, Ganser, Arnold, Förster, Reinhold, Prinz, Immo, Koenecke, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135231/ https://www.ncbi.nlm.nih.gov/pubmed/32251446 http://dx.doi.org/10.1371/journal.pone.0231222

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