EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY

Segmental and focal pathological changes were found in the glomeruli and tubules of postoperative renal-biopsy specimens from seven cases of clinically confirmed endemic (Balkan) nephropathy. In the glomeruli, there was mesangial reaction and segmental thickening of the basement membrane with subend...

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Detalles Bibliográficos
Autores principales: Apostolov, K, Spasic, P, Bojanic, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1975
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135235/
https://www.ncbi.nlm.nih.gov/pubmed/54796
http://dx.doi.org/10.1016/S0140-6736(75)90609-1
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author Apostolov, K
Spasic, P
Bojanic, N
author_facet Apostolov, K
Spasic, P
Bojanic, N
author_sort Apostolov, K
collection PubMed
description Segmental and focal pathological changes were found in the glomeruli and tubules of postoperative renal-biopsy specimens from seven cases of clinically confirmed endemic (Balkan) nephropathy. In the glomeruli, there was mesangial reaction and segmental thickening of the basement membrane with subendothelial and membranous depositions. In the tubules there was spongiform degeneration and fusion of cells. In all the cells of the nephron numerous cytoplasmic vesicles containing free and budding particles (80-200 nm) were found. These particles had the characteristics of a coronavirus. Balkan nephropathy occurs almost exclusively in people who have been in close contact with pigs. Coronaviruses have been isolated from pigs, and it is suggested that a slow coronavirus infection causes endemic nephropathy in man.
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spelling pubmed-71352352020-04-08 EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY Apostolov, K Spasic, P Bojanic, N Lancet Article Segmental and focal pathological changes were found in the glomeruli and tubules of postoperative renal-biopsy specimens from seven cases of clinically confirmed endemic (Balkan) nephropathy. In the glomeruli, there was mesangial reaction and segmental thickening of the basement membrane with subendothelial and membranous depositions. In the tubules there was spongiform degeneration and fusion of cells. In all the cells of the nephron numerous cytoplasmic vesicles containing free and budding particles (80-200 nm) were found. These particles had the characteristics of a coronavirus. Balkan nephropathy occurs almost exclusively in people who have been in close contact with pigs. Coronaviruses have been isolated from pigs, and it is suggested that a slow coronavirus infection causes endemic nephropathy in man. Published by Elsevier Ltd. 1975-12-27 2003-08-11 /pmc/articles/PMC7135235/ /pubmed/54796 http://dx.doi.org/10.1016/S0140-6736(75)90609-1 Text en Copyright © 1975 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Apostolov, K
Spasic, P
Bojanic, N
EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title_full EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title_fullStr EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title_full_unstemmed EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title_short EVIDENCE OF A VIRAL ÆTIOLOGY IN ENDEMIC (BALKAN) NEPHROPATHY
title_sort evidence of a viral ætiology in endemic (balkan) nephropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135235/
https://www.ncbi.nlm.nih.gov/pubmed/54796
http://dx.doi.org/10.1016/S0140-6736(75)90609-1
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