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Plant cell factories and mucosal vaccines

Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown t...

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Detalles Bibliográficos
Autores principales: Walmsley, Amanda M, Arntzen, Charles J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135315/
https://www.ncbi.nlm.nih.gov/pubmed/12732315
http://dx.doi.org/10.1016/S0958-1669(03)00026-0
Descripción
Sumario:Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown to protect against challenge in the target host. Increased antigen expression levels (up to 4.1% total soluble protein) have been obtained through transformation of the chloroplast genome. In view of these findings, plant-derived vaccines have been proved as valuable commodities to the world’s health system; however, before their application, studies need to focus on optimization of immunization strategies and to investigate antigen stability.