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TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the tr...

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Detalles Bibliográficos
Autores principales:	Sacramento, Laís Amorim, Benevides, Luciana, Maruyama, Sandra Regina, Tavares, Lucas, Fukutani, Kiyoshi Ferreira, Francozo, Marcela, Sparwasser, Tim, Cunha, Fernando Queiroz, Almeida, Roque Pacheco, da Silva, João Santana, Carregaro, Vanessa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135367/ https://www.ncbi.nlm.nih.gov/pubmed/32210480 http://dx.doi.org/10.1371/journal.ppat.1008435

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