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Performance of virtual screening against GPCR homology models: Impact of template selection and treatment of binding site plasticity
Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small number of available atomic resolution structures. We assessed the use of homology modeling to predict the structures of two therapeutically relevant GPCRs and strategies to improve the performance of virtual screeni...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135368/ https://www.ncbi.nlm.nih.gov/pubmed/32168319 http://dx.doi.org/10.1371/journal.pcbi.1007680 |