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Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte

INTRODUCTION: Respiratory syncytial virus (RSV) is rarely searched for in respiratory infections in adults. This study assessed its frequency and diagnosis. METHODS: Three separate studies were conducted in adults presenting with (1) a flu-like illness, (2) a lower respiratory tract infection in the...

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Autores principales: Freymuth, F., Vabret, A., Gouarin, S., Petitjean, J., Charbonneau, P., Lehoux, P., Galateau-Salle, F., Tremolières, F., Carette, M.-F., Mayaud, C., Mosnier, A., Burnouf, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SPLF. Published by Elsevier Masson SAS 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135519/
https://www.ncbi.nlm.nih.gov/pubmed/15260036
http://dx.doi.org/10.1016/S0761-8425(04)71233-4
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author Freymuth, F.
Vabret, A.
Gouarin, S.
Petitjean, J.
Charbonneau, P.
Lehoux, P.
Galateau-Salle, F.
Tremolières, F.
Carette, M.-F.
Mayaud, C.
Mosnier, A.
Burnouf, L.
author_facet Freymuth, F.
Vabret, A.
Gouarin, S.
Petitjean, J.
Charbonneau, P.
Lehoux, P.
Galateau-Salle, F.
Tremolières, F.
Carette, M.-F.
Mayaud, C.
Mosnier, A.
Burnouf, L.
author_sort Freymuth, F.
collection PubMed
description INTRODUCTION: Respiratory syncytial virus (RSV) is rarely searched for in respiratory infections in adults. This study assessed its frequency and diagnosis. METHODS: Three separate studies were conducted in adults presenting with (1) a flu-like illness, (2) a lower respiratory tract infection in the community, and (3) a severe pneumonia requiring hospitalisation. The diagnosis of RSV infection was sought by PCR in all cases, and compared to antigen detection and culture in two studies. RESULTS: RSV was identified in 20 (11.7%) of 170 influenza-vaccinated adults suffering from flu-like symptoms. In the 270 cases of non-severe lower respiratory tract illnesses in the community, viruses were identified in 86 (31.8%) cases, with RSV accounting for 13 (4.8%). In the 164 cases of acute bronchitis, a virus was detected in 64 (36.7%) of which 11 (6.3%) were RSV, 37 (21.3%) rhinovirus, 5 influenza viruses A and B, and 12 other viruses. In the 60 cases of infective exacerbations of chronic bronchitis, rhinovirus was detected in 9 (15%) and para-influenza 3 virus in 2 cases. In the 21 acute pneumonia's, 1 RSV, 1 influenza virus A and 2 rhinovirus cases were detected as well as 1 RSV, 1 parainfluenza 3 viruses and 4 rhinovirus cases in the 11 lower respiratory tract illnesses in patients with pre-existing lung disease. There were overall 19 viral and bacterial associated infections. Finally, in the 51 acute pneumonias hospitalised with respiratory distress syndrome, a virus was identified in 17 (33.3%) cases, including 3 (5.5%) RSV, 6 influenza A, 3 rhinovirus, 2 adenovirus, 2 herpes simplex virus and 1 cytomegalovirus. There were 6 bacterial-associated infections, and 4 were hospital-acquired. All RSV-infected patients were old people and had chronic pulmonary or cardiac disease. CONCLUSIONS: In adults, RSV is a frequent cause of flu-like symptoms. It can sometimes cause lower respiratory tract illness, which can be severe, and should be considered in the differential diagnosis in such cases. The PCR method is a particularly effective diagnostic test, but as yet is not routinely available.
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spelling pubmed-71355192020-04-08 Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte Freymuth, F. Vabret, A. Gouarin, S. Petitjean, J. Charbonneau, P. Lehoux, P. Galateau-Salle, F. Tremolières, F. Carette, M.-F. Mayaud, C. Mosnier, A. Burnouf, L. Rev Mal Respir Article Original INTRODUCTION: Respiratory syncytial virus (RSV) is rarely searched for in respiratory infections in adults. This study assessed its frequency and diagnosis. METHODS: Three separate studies were conducted in adults presenting with (1) a flu-like illness, (2) a lower respiratory tract infection in the community, and (3) a severe pneumonia requiring hospitalisation. The diagnosis of RSV infection was sought by PCR in all cases, and compared to antigen detection and culture in two studies. RESULTS: RSV was identified in 20 (11.7%) of 170 influenza-vaccinated adults suffering from flu-like symptoms. In the 270 cases of non-severe lower respiratory tract illnesses in the community, viruses were identified in 86 (31.8%) cases, with RSV accounting for 13 (4.8%). In the 164 cases of acute bronchitis, a virus was detected in 64 (36.7%) of which 11 (6.3%) were RSV, 37 (21.3%) rhinovirus, 5 influenza viruses A and B, and 12 other viruses. In the 60 cases of infective exacerbations of chronic bronchitis, rhinovirus was detected in 9 (15%) and para-influenza 3 virus in 2 cases. In the 21 acute pneumonia's, 1 RSV, 1 influenza virus A and 2 rhinovirus cases were detected as well as 1 RSV, 1 parainfluenza 3 viruses and 4 rhinovirus cases in the 11 lower respiratory tract illnesses in patients with pre-existing lung disease. There were overall 19 viral and bacterial associated infections. Finally, in the 51 acute pneumonias hospitalised with respiratory distress syndrome, a virus was identified in 17 (33.3%) cases, including 3 (5.5%) RSV, 6 influenza A, 3 rhinovirus, 2 adenovirus, 2 herpes simplex virus and 1 cytomegalovirus. There were 6 bacterial-associated infections, and 4 were hospital-acquired. All RSV-infected patients were old people and had chronic pulmonary or cardiac disease. CONCLUSIONS: In adults, RSV is a frequent cause of flu-like symptoms. It can sometimes cause lower respiratory tract illness, which can be severe, and should be considered in the differential diagnosis in such cases. The PCR method is a particularly effective diagnostic test, but as yet is not routinely available. SPLF. Published by Elsevier Masson SAS 2004-02 2008-01-03 /pmc/articles/PMC7135519/ /pubmed/15260036 http://dx.doi.org/10.1016/S0761-8425(04)71233-4 Text en © 2004 SPLF Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article Original
Freymuth, F.
Vabret, A.
Gouarin, S.
Petitjean, J.
Charbonneau, P.
Lehoux, P.
Galateau-Salle, F.
Tremolières, F.
Carette, M.-F.
Mayaud, C.
Mosnier, A.
Burnouf, L.
Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title_full Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title_fullStr Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title_full_unstemmed Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title_short Épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
title_sort épidémiologie et diagnostic des infections à virus respiratoire syncytial de l’adulte
topic Article Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135519/
https://www.ncbi.nlm.nih.gov/pubmed/15260036
http://dx.doi.org/10.1016/S0761-8425(04)71233-4
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