Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus

At a concentration of 2 μg/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis Coronavirus in-fectivity. However, amphothericin B stimulated plaque formatin in agarose and facilitated the entry of viral RNA into swine testis cells. The combinatio...

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Detalles Bibliográficos
Autores principales: Nguyen, T.D., Bottreau, E., Aynaud, J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS 1987
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135538/
https://www.ncbi.nlm.nih.gov/pubmed/32288187
http://dx.doi.org/10.1016/S0769-2617(87)80019-9
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author Nguyen, T.D.
Bottreau, E.
Aynaud, J.M.
author_facet Nguyen, T.D.
Bottreau, E.
Aynaud, J.M.
author_sort Nguyen, T.D.
collection PubMed
description At a concentration of 2 μg/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis Coronavirus in-fectivity. However, amphothericin B stimulated plaque formatin in agarose and facilitated the entry of viral RNA into swine testis cells. The combination of amphotericin B + deoxycholate inactivated virus infectivity and induced a decrease in plaque diameter. Finally, in the presence of these agents, the production of infectious virus and interferon was unchanged.
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spelling pubmed-71355382020-04-08 Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus Nguyen, T.D. Bottreau, E. Aynaud, J.M. Ann Inst Pasteur Virol Article At a concentration of 2 μg/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis Coronavirus in-fectivity. However, amphothericin B stimulated plaque formatin in agarose and facilitated the entry of viral RNA into swine testis cells. The combination of amphotericin B + deoxycholate inactivated virus infectivity and induced a decrease in plaque diameter. Finally, in the presence of these agents, the production of infectious virus and interferon was unchanged. Published by Elsevier Masson SAS 1987 2009-09-23 /pmc/articles/PMC7135538/ /pubmed/32288187 http://dx.doi.org/10.1016/S0769-2617(87)80019-9 Text en Copyright © 1987 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nguyen, T.D.
Bottreau, E.
Aynaud, J.M.
Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title_full Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title_fullStr Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title_full_unstemmed Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title_short Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
title_sort effect of deoxycholate, amphotericin b and fongizone on transmissible gastroenteritis coronavirus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135538/
https://www.ncbi.nlm.nih.gov/pubmed/32288187
http://dx.doi.org/10.1016/S0769-2617(87)80019-9
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