Cargando…
The where, what and how of ribosomal frameshifting in retroviral protein synthesis
The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the −1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals wi...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Ltd.
1990
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135620/ https://www.ncbi.nlm.nih.gov/pubmed/2193436 http://dx.doi.org/10.1016/0968-0004(90)90159-9 |
| Sumario: | The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the −1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals within the RNA: one is a heptanucleotide stretch at the frameshift site and the other is a stem-loop structure which occurs just downstream of the first signal. |
|---|