The where, what and how of ribosomal frameshifting in retroviral protein synthesis

The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the −1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals wi...

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Detalles Bibliográficos
Autores principales: Hatfield, Dolph, Oroszlan, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135620/
https://www.ncbi.nlm.nih.gov/pubmed/2193436
http://dx.doi.org/10.1016/0968-0004(90)90159-9
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author Hatfield, Dolph
Oroszlan, Stephen
author_facet Hatfield, Dolph
Oroszlan, Stephen
author_sort Hatfield, Dolph
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description The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the −1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals within the RNA: one is a heptanucleotide stretch at the frameshift site and the other is a stem-loop structure which occurs just downstream of the first signal.
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spelling pubmed-71356202020-04-08 The where, what and how of ribosomal frameshifting in retroviral protein synthesis Hatfield, Dolph Oroszlan, Stephen Trends Biochem Sci Article The gag and pol genes of most retroviruses occur in different reading frames and their translation as a single polypeptide is carried out by ribosomal frameshifting in the −1 direction. The alignment of the different reading frames occurs by overlapping reading in response to at least two signals within the RNA: one is a heptanucleotide stretch at the frameshift site and the other is a stem-loop structure which occurs just downstream of the first signal. Published by Elsevier Ltd. 1990-05 2003-03-21 /pmc/articles/PMC7135620/ /pubmed/2193436 http://dx.doi.org/10.1016/0968-0004(90)90159-9 Text en Copyright © 1990 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hatfield, Dolph
Oroszlan, Stephen
The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title_full The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title_fullStr The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title_full_unstemmed The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title_short The where, what and how of ribosomal frameshifting in retroviral protein synthesis
title_sort where, what and how of ribosomal frameshifting in retroviral protein synthesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135620/
https://www.ncbi.nlm.nih.gov/pubmed/2193436
http://dx.doi.org/10.1016/0968-0004(90)90159-9
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