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Epitope spreading

Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to...

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Detalles Bibliográficos
Autores principales: Vanderlugt, Carol J, Miller, Stephen D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135770/
https://www.ncbi.nlm.nih.gov/pubmed/8994863
http://dx.doi.org/10.1016/S0952-7915(96)80012-4
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author Vanderlugt, Carol J
Miller, Stephen D
author_facet Vanderlugt, Carol J
Miller, Stephen D
author_sort Vanderlugt, Carol J
collection PubMed
description Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell-mediated and antibody-mediated autoimmune diseases. Most significantly, conclusive functional evidence for a major role for epitope spreading in the chronic pathogenesis of murine relapsing-remitting experimental autoimmune encephalomyelitis, a CD4(+) T-cell-mediated model of multiple sclerosis, was forthcoming.
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spelling pubmed-71357702020-04-08 Epitope spreading Vanderlugt, Carol J Miller, Stephen D Curr Opin Immunol Article Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell-mediated and antibody-mediated autoimmune diseases. Most significantly, conclusive functional evidence for a major role for epitope spreading in the chronic pathogenesis of murine relapsing-remitting experimental autoimmune encephalomyelitis, a CD4(+) T-cell-mediated model of multiple sclerosis, was forthcoming. Published by Elsevier Ltd. 1996-12 2002-02-11 /pmc/articles/PMC7135770/ /pubmed/8994863 http://dx.doi.org/10.1016/S0952-7915(96)80012-4 Text en Copyright © 1996 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Vanderlugt, Carol J
Miller, Stephen D
Epitope spreading
title Epitope spreading
title_full Epitope spreading
title_fullStr Epitope spreading
title_full_unstemmed Epitope spreading
title_short Epitope spreading
title_sort epitope spreading
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135770/
https://www.ncbi.nlm.nih.gov/pubmed/8994863
http://dx.doi.org/10.1016/S0952-7915(96)80012-4
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