ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS

The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma. In this group the plasma-theophylline half-life (mean=419·8 min) was significantly longer during the acute stage of their il...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, K.C., Lauer, B.A., Bell, T.D., Chai, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1978
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135825/
https://www.ncbi.nlm.nih.gov/pubmed/77421
http://dx.doi.org/10.1016/S0140-6736(78)90305-7
_version_ 1783518143556091904
author Chang, K.C.
Lauer, B.A.
Bell, T.D.
Chai, H.
author_facet Chang, K.C.
Lauer, B.A.
Bell, T.D.
Chai, H.
author_sort Chang, K.C.
collection PubMed
description The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma. In this group the plasma-theophylline half-life (mean=419·8 min) was significantly longer during the acute stage of their illness than 1 month later (mean 249·9 min). There was no appreciable change in half-life in 4 patients who were febrile but in whom seroconversion did not occur. These preliminary results suggest that certain upper-respiratory-tract viral infections may affect theophylline metabolism.
format Online
Article
Text
id pubmed-7135825
institution National Center for Biotechnology Information
language English
publishDate 1978
publisher Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71358252020-04-08 ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS Chang, K.C. Lauer, B.A. Bell, T.D. Chai, H. Lancet Article The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma. In this group the plasma-theophylline half-life (mean=419·8 min) was significantly longer during the acute stage of their illness than 1 month later (mean 249·9 min). There was no appreciable change in half-life in 4 patients who were febrile but in whom seroconversion did not occur. These preliminary results suggest that certain upper-respiratory-tract viral infections may affect theophylline metabolism. Published by Elsevier Ltd. 1978-05-27 2003-09-20 /pmc/articles/PMC7135825/ /pubmed/77421 http://dx.doi.org/10.1016/S0140-6736(78)90305-7 Text en Copyright © 1978 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chang, K.C.
Lauer, B.A.
Bell, T.D.
Chai, H.
ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title_full ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title_fullStr ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title_full_unstemmed ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title_short ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS
title_sort altered theophylline pharmacokinetics during acute respiratory viral illness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135825/
https://www.ncbi.nlm.nih.gov/pubmed/77421
http://dx.doi.org/10.1016/S0140-6736(78)90305-7
work_keys_str_mv AT changkc alteredtheophyllinepharmacokineticsduringacuterespiratoryviralillness
AT lauerba alteredtheophyllinepharmacokineticsduringacuterespiratoryviralillness
AT belltd alteredtheophyllinepharmacokineticsduringacuterespiratoryviralillness
AT chaih alteredtheophyllinepharmacokineticsduringacuterespiratoryviralillness

Ejemplares similares