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Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

Osteolytic bone disease is characterized by excessive osteoclast bone resorption leading to increased skeletal fragility and fracture risk. Multinucleated osteoclasts formed through the fusion of mononuclear precursors are the principle cell capable of bone resorption. Pregnenolone (Preg) is the gra...

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Detalles Bibliográficos
Autores principales:	Sun, Xiaochen, Zhang, Chenxi, Guo, Huan, Chen, Jiao, Tao, Yali, Wang, Fuxiao, Lin, Xixi, Liu, Qian, Su, Li, Qin, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135856/ https://www.ncbi.nlm.nih.gov/pubmed/32292342 http://dx.doi.org/10.3389/fphar.2020.00360

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